Conventional / global / constitutive KO
●2 Models Available
Chek1 Conditional Knockout, Knockout mouse models
Browse 2 Chek1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Chek1 conditional knockout mouse, Chek1 knockout mouse. Contact us for availability and fast turnaround.
Why model Chek1
Chek1, the mouse ortholog of human CHEK1, encodes CHK1, the effector kinase of the replication checkpoint, recruited to chromatin through CLASPIN and activated by ATR phosphorylation at serines 317 and 345, after which it phosphorylates CDC25A to trigger its degradation, inhibits CDK2 driven origin firing, restrains CDC45 loading, stabilizes stalled forks and enforces the G2/M transition through CDC25C and WEE1. Loss is cell lethal because unrestrained origin firing exhausts nucleotide and RPA pools, and homozygous null embryos die at the blastocyst stage, while heterozygotes show genuine haploinsufficiency with checkpoint defects, so this is a gene where conditional floxed alleles and inducible Cre are not optional. Acute deletion in adult intestine or hematopoietic compartments reproduces the on-target toxicity that limits CHK1 inhibitors clinically, making it the right platform for therapeutic window studies. Chek2 does not substitute, since it operates downstream of ATM on double strand breaks. Reserve hypomorphic alleles for chronic replication stress and conditional nulls for acute dependency work.
What Chek1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Chek1 (CHEK1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Chek1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Chek1 allele types
Knockout, conditional, knockin, humanized, and related paths for Chek1 (human CHEK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Chek1 catalog models
2 Chek1 lines with QC documentation and technical support. Chek1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Chek1 mouse model?
We have 2 Chek1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Chek1 Mouse Model Types
A Chek1 knockout mouse has the Chek1 gene permanently inactivated, enabling loss of function studies. A Chek1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Chek1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Chek1 organized by modification type. Each URL is indexable and matches common search patterns.