Conventional / global / constitutive KO
●2 Models Available
Chek2 Conditional Knockout, Knockout mouse models
Browse 2 Chek2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Chek2 conditional knockout mouse, Chek2 knockout mouse. Contact us for availability and fast turnaround.
Why model Chek2
Chek2, mouse ortholog of human CHEK2, encodes CHK2, an ATM effector kinase built from an SQ/TQ cluster, an FHA phosphopeptide binding domain and a kinase domain, activated when ATM phosphorylates threonine 68 to promote FHA-mediated dimerization and trans-autophosphorylation at the activation loop. Active CHK2 phosphorylates p53 at serine 20 to disrupt MDM2 binding, targets CDC25A and CDC25C for degradation or 14-3-3 sequestration, and phosphorylates BRCA1 and E2F1, enforcing G1 arrest and apoptosis after double strand breaks. The truncating 1100delC and missense I157T alleles confer moderate breast and prostate cancer risk, making patient-variant knockins the appropriate tool for penetrance and variant reclassification studies. Null mice are viable and radioresistant in thymocytes with defective p53 stabilization, so constitutive alleles are entirely workable, unlike Chek1. Because CHK2 acts on breaks and CHK1 on replication stress, they are not redundant. Choose nulls for apoptotic threshold and radiation response, and knockins for allele-specific cancer risk modeling.
What Chek2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Chek2 (CHEK2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Chek2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Chek2 allele types
Knockout, conditional, knockin, humanized, and related paths for Chek2 (human CHEK2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Chek2 catalog models
2 Chek2 lines with QC documentation and technical support. Chek2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Chek2 mouse model?
We have 2 Chek2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Chek2 Mouse Model Types
A Chek2 knockout mouse has the Chek2 gene permanently inactivated, enabling loss of function studies. A Chek2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Chek2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Chek2 organized by modification type. Each URL is indexable and matches common search patterns.