Conventional / global / constitutive KO
●2 Models Available
Ctla4 Conditional Knockout, Knockout mouse models
Browse 2 Ctla4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ctla4 conditional knockout mouse, Ctla4 knockout mouse. Contact us for availability and fast turnaround.
Why model Ctla4
Ctla4, ortholog of human CTLA4, encodes CD152, an inhibitory CD28 family homodimer that shares the MYPPPY ligand motif but binds CD80 and CD86 with far higher avidity, outcompeting CD28 and physically stripping ligands from antigen presenting cells by transendocytosis, a cell-extrinsic mechanism central to regulatory T cell suppression. Surface residence is brief because the cytoplasmic YVKM motif recruits AP-2 for constitutive clathrin-mediated internalization and LRBA-dependent recycling, and the same motif engages PP2A and SHP-2. Germline deletion is catastrophic, with fatal lymphoproliferation, myocarditis, and pancreatitis by three to four weeks, so adult studies demand conditional flox alleles with Foxp3-Cre or Cd4-CreER to separate regulatory from conventional T cell requirements. No paralog compensates, since CD28 is the functional antagonist rather than a substitute. Humanized CTLA4 knockins are essential for ipilimumab and Fc-engineered antibody work, and haploinsufficient alleles suit human CTLA4 insufficiency and LRBA deficiency biology.
What Ctla4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ctla4 (CTLA4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ctla4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ctla4 allele types
Knockout, conditional, knockin, humanized, and related paths for Ctla4 (human CTLA4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ctla4 catalog models
2 Ctla4 lines with QC documentation and technical support. Ctla4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ctla4 mouse model?
We have 2 Ctla4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ctla4 Mouse Model Types
A Ctla4 knockout mouse has the Ctla4 gene permanently inactivated, enabling loss of function studies. A Ctla4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ctla4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ctla4 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Ctla4.