Conventional / global / constitutive KO
●3 Models Available
Ctsg Conditional Knockout, Knockout mouse models
Browse 3 Ctsg mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ctsg conditional knockout mouse, Ctsg knockout mouse. Request a quote within 24 hours.
Why model Ctsg
Ctsg, ortholog of human CTSG, encodes cathepsin G, a chymotrypsin-family serine protease stored in mature form within neutrophil azurophilic granules alongside elastase and proteinase 3. Cathepsin G is unusual in possessing dual chymase-like and tryptase-like specificity, allowing it to process angiotensin, activate PAR4 on platelets, convert chemokines and cytokines, kill bacteria through combined catalytic and cationic antimicrobial activity, and decorate neutrophil extracellular traps. Maturation of cathepsin G, elastase, and proteinase 3 all requires dipeptidyl peptidase I (cathepsin C, Ctsc) removal of the activation dipeptide, so Ctsc deficiency phenocopies triple protease loss and offers a useful genetic shortcut. Because Elane and Prtn3 overlap substantially in substrate range and granule localization, single Ctsg nulls show only partial defects in bacterial killing and compound alleles are needed for clear phenotypes. Reserve humanization for inhibitor pharmacology where chymase pocket specificity differs by species, and use granulocyte-restricted conditional deletion for tissue injury endpoints.
What Ctsg mouse models are available?
ingenious targeting laboratory offers 3 distinct Ctsg (CTSG) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ctsg model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ctsg allele types
Knockout, conditional, knockin, humanized, and related paths for Ctsg (human CTSG). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ctsg catalog models
3 Ctsg lines with QC documentation and technical support. Ctsg floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ctsg mouse model?
We have 3 Ctsg models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ctsg Mouse Model Types
A Ctsg knockout mouse has the Ctsg gene permanently inactivated, enabling loss of function studies. A Ctsg conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ctsg, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ctsg organized by modification type. Each URL is indexable and matches common search patterns.