Conventional / global / constitutive KO
●3 Models Available
Ctsb Conditional Knockout, Knockout mouse models
Browse 3 Ctsb mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ctsb conditional knockout mouse, Ctsb knockout mouse. Contact us for availability and fast turnaround.
Why model Ctsb
Mouse Ctsb, ortholog of human CTSB, encodes cathepsin B, a papain-family lysosomal cysteine protease distinguished by an occluding loop that folds over the primed subsites, conferring carboxydipeptidase activity in addition to endopeptidase function. The proenzyme is trafficked by mannose-6-phosphate receptors and activated at acidic pH by autocatalysis or by cathepsin D and legumain, and its substrates span bulk lysosomal turnover, maturation of other proenzymes, extracellular matrix components after secretion, and inflammatory mediators, with lysosomal leakage of cathepsin B implicated in NLRP3 inflammasome activation, tumor invasion, and necrotic death. Nulls are viable and fertile, partly because cathepsins L, Z, and S share substrate space, so meaningful phenotypes often require compound Ctsb Ctsl or Ctsb Ctsz alleles. Use conditional deletion with myeloid or tumor cell Cre when localizing the relevant protease pool, and active site or occluding loop knockins when endopeptidase versus exopeptidase activity is the mechanistic question.
What Ctsb mouse models are available?
ingenious targeting laboratory offers 3 distinct Ctsb (CTSB) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ctsb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ctsb allele types
Knockout, conditional, knockin, humanized, and related paths for Ctsb (human CTSB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ctsb catalog models
3 Ctsb lines with QC documentation and technical support. Ctsb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ctsb mouse model?
We have 3 Ctsb models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ctsb Mouse Model Types
A Ctsb knockout mouse has the Ctsb gene permanently inactivated, enabling loss of function studies. A Ctsb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ctsb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ctsb organized by modification type. Each URL is indexable and matches common search patterns.