Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
SPERM
Dhh Conditional Knockout, Knockin mouse models
Browse 3 Dhh mouse models including conditional knockout, knockin variants from ingenious targeting laboratory. Available as Dhh conditional knockout mouse, Dhh knockin mouse. Contact us for availability and fast turnaround.
Why model Dhh
Dhh, mouse ortholog of human DHH, encodes Desert hedgehog, an autoprocessing morphogen that undergoes intramolecular cleavage with cholesterol modification and palmitoylation before binding PTCH1 to relieve inhibition of SMO, stabilizing GLI2 and GLI3 for target transcription. Unlike the broadly expressed SHH, its expression is restricted chiefly to Sertoli cells, where it acts on peritubular and Leydig progenitors to drive steroidogenic differentiation, and to Schwann cells, where it builds the perineurium and nerve-blood barrier. Human biallelic mutations cause 46,XY gonadal dysgenesis with or without minifascicular polyneuropathy, a phenotype well matched by patient-derived missense knockins that impair processing or receptor binding. Mouse nulls are viable but males show Leydig hypoplasia, infertility, and abnormal nerve sheaths, so constitutive deletion is workable while conditional floxed alleles with Amh-Cre or Dhh-Cre separate testicular from peripheral nerve requirements. Because Shh and Ihh signal through the same PTCH1 and SMO machinery, interpret pathway-level readouts with paralog expression documented for the tissue scored.
What Dhh mouse models are available?
ingenious targeting laboratory offers 3 distinct Dhh (DHH) catalog mouse models in the Hedgehog family, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dhh model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dhh allele types
Knockout, conditional, knockin, humanized, and related paths for Dhh (human DHH). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dhh catalog models
3 Dhh lines with QC documentation and technical support. Dhh floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Dhh-Flox
CKOCKO
These mice carry loxP sites flanking exon 1 of Dhh gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dhh gene.
Sperm CryopreservedCKO 251668 - Order
Dhh-CreERT2
KICre/Dre Toolbox
Kozak-CreERT2-WPRE-pA expression cassette was knocked into the Dhh gene .
Sperm CryopreservedKI 225050 - Order
Dhh-Cre
KICre/Dre Toolbox
Kozak-Cre-WPRE-pA expression cassette was knocked into the Dhh gene .
Sperm CryopreservedKI 225049
Looking for a Dhh mouse model?
We have 3 Dhh models available — including Conditional Knockout, Knockin types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dhh Mouse Model Types
A Dhh conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dhh, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Dhh knockin models carry a precisely inserted sequence at the Dhh locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Dhh organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Dhh line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.