Conventional / global / constitutive KO
●4 Models Available
Dhh Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Dhh mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Dhh conditional knockout mouse, Dhh knockin mouse, Dhh knockout mouse. Request a quote within 24 hours.
Why model Dhh
Dhh, mouse ortholog of human DHH, encodes Desert hedgehog, an autoprocessing morphogen that undergoes intramolecular cleavage with cholesterol modification and palmitoylation before binding PTCH1 to relieve inhibition of SMO, stabilizing GLI2 and GLI3 for target transcription. Unlike the broadly expressed SHH, its expression is restricted chiefly to Sertoli cells, where it acts on peritubular and Leydig progenitors to drive steroidogenic differentiation, and to Schwann cells, where it builds the perineurium and nerve-blood barrier. Human biallelic mutations cause 46,XY gonadal dysgenesis with or without minifascicular polyneuropathy, a phenotype well matched by patient-derived missense knockins that impair processing or receptor binding. Mouse nulls are viable but males show Leydig hypoplasia, infertility, and abnormal nerve sheaths, so constitutive deletion is workable while conditional floxed alleles with Amh-Cre or Dhh-Cre separate testicular from peripheral nerve requirements. Because Shh and Ihh signal through the same PTCH1 and SMO machinery, interpret pathway-level readouts with paralog expression documented for the tissue scored.
What Dhh mouse models are available?
ingenious targeting laboratory offers 4 distinct Dhh (DHH) catalog mouse models in the Hedgehog family, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dhh model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dhh allele types
Knockout, conditional, knockin, humanized, and related paths for Dhh (human DHH). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dhh catalog models
4 Dhh lines with QC documentation and technical support. Dhh floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Dhh mouse model?
We have 4 Dhh models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dhh Mouse Model Types
A Dhh knockout mouse has the Dhh gene permanently inactivated, enabling loss of function studies. A Dhh conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dhh, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Dhh knockin models carry a precisely inserted sequence at the Dhh locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Dhh organized by modification type. Each URL is indexable and matches common search patterns.