Dlg3 Knockout mouse models
Dlg3 encodes SAP102, ortholog of human DLG3, a membrane-associated guanylate kinase distinguished from PSD-95 by the absence of N-terminal palmitoylation and by an alternatively spliced insert that binds mPins and exportin, features that make it the dominant NMDA receptor scaffold in immature synapses where it preferentially associates with GluN2B-containing receptors and supports their delivery before PSD-95 and PSD-93 take over. Its PDZ domains also engage GluA2 and the exocyst, giving it a role in receptor trafficking as well as anchoring. Truncating mutations in the X-linked human gene cause nonsyndromic intellectual disability, so hemizygous male mice provide a directly comparable dosage model. Constitutive nulls are viable with impaired learning and altered synaptic plasticity, though the developmental window matters: phenotypes are strongest early and are progressively masked as Dlg4 and Dlg2 expression rises. Plan conditional deletion with early drivers such as Nes-Cre and score juvenile plasticity rather than adult endpoints alone.
Dlg3 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Dlg3 Knockout mouse models are available?
ingenious targeting laboratory offers 2 distinct Dlg3 knockout catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Dlg3 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Dlg3 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Dlg3 Knockout mouse models are available?
When Dlg3 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Dlg3 knockout embryonic lethal in mice?
It depends on background and allele design. Some Dlg3 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Dlg3 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Dlg3?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.