Conventional / global / constitutive KO
●3 Models Available
Dll3 Conditional Knockout, Knockout mouse models
Browse 3 Dll3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Dll3 conditional knockout mouse, Dll3 knockout mouse. Contact us for availability and fast turnaround.
Why model Dll3
Dll3, the mouse ortholog of human DLL3, encodes a divergent Delta-like protein that lacks a functional DSL domain and fails to trans-activate Notch, instead accumulating in the Golgi and late endosomes where it acts as a cis-inhibitor by retaining NOTCH1 and DLL1 and preventing their surface presentation, thereby modulating the segmentation clock. Loss in mouse yields the pudgy phenotype with severely disorganized vertebrae and ribs, matching human biallelic mutations that cause spondylocostal dysostosis type 1, so constitutive nulls are directly informative for axial skeletal endpoints. The dominant contemporary interest is oncologic: aberrant surface expression in small cell lung cancer and neuroendocrine tumors makes the protein a target for antibody drug conjugates, bispecific T cell engagers such as tarlatamab, and CAR designs, none of which cross-react between species. Consequently, epitope-matched humanized knockins are the correct allele for efficacy and on-target toxicity studies, while floxed conditionals suit developmental questions. Related Dll1 partially overlaps in presomitic mesoderm but cannot substitute for cis-inhibition.
What Dll3 mouse models are available?
ingenious targeting laboratory offers 3 distinct Dll3 (DLL3) catalog mouse models in the Notch ligand family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dll3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dll3 allele types
Knockout, conditional, knockin, humanized, and related paths for Dll3 (human DLL3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dll3 catalog models
3 Dll3 lines with QC documentation and technical support. Dll3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Dll3 mouse model?
We have 3 Dll3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dll3 Mouse Model Types
A Dll3 knockout mouse has the Dll3 gene permanently inactivated, enabling loss of function studies. A Dll3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dll3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Dll3 organized by modification type. Each URL is indexable and matches common search patterns.