Conventional / global / constitutive KO
●1 Model Available
Dnmt1 Conditional Knockout mouse model
Browse 1 Dnmt1 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Dnmt1
Maintenance of CpG methylation depends on Dnmt1, the mouse ortholog of human DNMT1, whose catalytic domain is held autoinhibited by CXXC and BAH modules until UHRF1 delivers hemimethylated DNA and ubiquitinates histone H3, while PCNA tethering couples the enzyme to the replication fork. Loss produces genome-wide hypomethylation, retroelement derepression, loss of imprinting, and chromosomal instability, and homozygous deletion is embryonic lethal around E9.5, whereas hypomorphic alleles that reduce activity to a fraction of normal survive and develop thymic lymphoma, demonstrating that graded dosage rather than binary loss drives tumor phenotypes. Design choices follow directly: hypomorphic and conditional alleles address graded hypomethylation and tumor susceptibility, catalytically dead knockins separate methyltransferase output from scaffolding, and knockins supporting hypomethylating agent studies address pharmacology. The de novo enzymes Dnmt3a and Dnmt3b cannot restore maintenance activity, so assume no compensation when interpreting conditional deletion in adult tissues.
What Dnmt1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Dnmt1 (DNMT1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dnmt1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dnmt1 allele types
Knockout, conditional, knockin, humanized, and related paths for Dnmt1 (human DNMT1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dnmt1 catalog models
1 Dnmt1 line with QC documentation and technical support. Dnmt1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Dnmt1-Flox
Conditional KnockoutKO/CKO mice
liveCKO 190046
Looking for a Dnmt1 mouse model?
We have 1 Dnmt1 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dnmt1 Mouse Model Types
A Dnmt1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dnmt1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Dnmt1 organized by modification type. Each URL is indexable and matches common search patterns.