Conventional / global / constitutive KO
●2 Models Available
Dnmt3a Conditional Knockout, Knockin mouse models
Browse 2 Dnmt3a mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Dnmt3a conditional knockout mouse, Dnmt3a knockin mouse. Request a quote within 24 hours.
Why model Dnmt3a
De novo methylation in hematopoiesis is dominated by Dnmt3a, ortholog of human DNMT3A, whose ADD domain is released from autoinhibition upon reading unmethylated H3K4, whose PWWP domain docks on H3K36 dimethylation to direct intergenic and heterochromatic targeting, and whose catalytic domain forms active tetramers with DNMT3L or DNMT3B. The leukemia hotspot R882H sits at the substrate binding interface and acts dominantly by poisoning tetramer formation, reducing methylation output well below simple haploinsufficiency and driving clonal hematopoiesis, AML, and T cell lymphoma. Design should therefore distinguish a conditional null, which reports stem cell self-renewal and differentiation blockade, from an inducible R882H knockin, which reproduces the dominant-negative epigenetic state seen in patients. Constitutive nulls survive gestation but die within weeks after birth, so conditional deletion with Mx1-Cre or Vav-Cre plus transplantation is standard. Dnmt3b overlaps only partially, and compound deletion collapses methylation far more severely than either allele alone.
What Dnmt3a mouse models are available?
ingenious targeting laboratory offers 2 distinct Dnmt3a (DNMT3A) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dnmt3a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dnmt3a allele types
Knockout, conditional, knockin, humanized, and related paths for Dnmt3a (human DNMT3A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dnmt3a catalog models
2 Dnmt3a lines with QC documentation and technical support. Dnmt3a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Dnmt3a mouse model?
We have 2 Dnmt3a models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dnmt3a Mouse Model Types
A Dnmt3a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dnmt3a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Dnmt3a knockin models carry a precisely inserted sequence at the Dnmt3a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Dnmt3a organized by modification type. Each URL is indexable and matches common search patterns.