Conventional / global / constitutive KO
●2 Models Available
F10 Conditional Knockout, Knockout mouse models
Browse 2 F10 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as F10 conditional knockout mouse, F10 knockout mouse. Contact us for availability and fast turnaround.
Why model F10
F10 encodes coagulation factor X, the mouse ortholog of human F10 and the convergence point of the intrinsic and extrinsic cascades. The vitamin K dependent zymogen carries an amino-terminal Gla domain whose gamma-carboxyglutamate residues mediate calcium-dependent phospholipid binding, two EGF-like modules, and a trypsin-like protease domain; activation by the tissue factor and factor VIIa complex or by the factor IXa and factor VIIIa intrinsic tenase generates factor Xa, which assembles with factor Va on activated platelet membranes into prothrombinase to convert prothrombin to thrombin, and is checked by antithrombin and tissue factor pathway inhibitor. Complete deficiency is not survivable in mouse, causing embryonic and perinatal lethality from hemorrhage, so hypomorphic or conditional alleles are required for adult phenotyping. Low-expressing knockins that titrate factor X to a few percent of normal are the established route for bleeding and thrombosis endpoints, whereas humanized knockins suit direct oral anticoagulant and reversal agent pharmacology.
What F10 mouse models are available?
ingenious targeting laboratory offers 2 distinct F10 (F10) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
F10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
F10 allele types
Knockout, conditional, knockin, humanized, and related paths for F10 (human F10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available F10 catalog models
2 F10 lines with QC documentation and technical support. F10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a F10 mouse model?
We have 2 F10 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About F10 Mouse Model Types
A F10 knockout mouse has the F10 gene permanently inactivated, enabling loss of function studies. A F10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of F10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for F10 organized by modification type. Each URL is indexable and matches common search patterns.