Conventional / global / constitutive KO
●2 Models Available
F12 Conditional Knockout, Knockout mouse models
Browse 2 F12 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as F12 conditional knockout mouse, F12 knockout mouse. Contact us for availability and fast turnaround.
Why model F12
F12 encodes factor XII (Hageman factor), the mouse ortholog of human F12, a zymogen with fibronectin type I and II, EGF, and kringle domains plus a proline-rich region that autoactivates upon contact with polyanionic surfaces including polyphosphate, misfolded protein aggregates, collagen, and artificial materials. Factor XIIa then cleaves prekallikrein to plasma kallikrein, which reciprocally amplifies factor XII activation and liberates bradykinin from high molecular weight kininogen, and it activates factor XI to feed intrinsic coagulation. This dual output makes F12 the entry point for both contact-driven thrombosis and kinin-mediated vascular permeability, with human gain-of-function variants such as Thr309Lys causing hereditary angioedema despite normal C1 inhibitor. Nulls display normal hemostasis yet are protected in arterial thrombosis and stroke models, precisely the dissociation of interest. Knockins of angioedema-associated alleles are the design for permeability and attack-driven endpoints, whereas humanization supports antibody and antisense programs directed at human factor XII.
What F12 mouse models are available?
ingenious targeting laboratory offers 2 distinct F12 (F12) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
F12 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
F12 allele types
Knockout, conditional, knockin, humanized, and related paths for F12 (human F12). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available F12 catalog models
2 F12 lines with QC documentation and technical support. F12 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a F12 mouse model?
We have 2 F12 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About F12 Mouse Model Types
A F12 knockout mouse has the F12 gene permanently inactivated, enabling loss of function studies. A F12 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of F12, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for F12 organized by modification type. Each URL is indexable and matches common search patterns.