Conventional / global / constitutive KO
●2 Models Available
F5 Conditional Knockout, Knockout mouse models
Browse 2 F5 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as F5 conditional knockout mouse, F5 knockout mouse. Request a quote within 24 hours.
Why model F5
Mouse F5 is the ortholog of human F5 and encodes factor V, the nonenzymatic cofactor that raises factor Xa catalytic efficiency toward prothrombin by several orders of magnitude. Synthesized with A1, A2, B, A3, C1, and C2 domains, factor V is activated by thrombin or factor Xa cleavage that releases the large inhibitory B domain, allowing heterodimeric factor Va to bind membrane phosphatidylserine through its C2 discoidin domain and assemble prothrombinase. Downregulation occurs by activated protein C cleavage at Arg306, Arg506, and Arg679, and the human Leiden variant substituting Arg506 with glutamine confers APC resistance and thrombophilia, a mutation class best modeled by homologous knockin rather than null. Complete deficiency is lethal in mouse from embryonic and perinatal hemorrhage, so hypomorphic or conditional alleles are required, while the East Texas splice variant illustrates additional TFPI-related regulatory function. Pair Leiden knockins with thrombosis challenge endpoints and conditional alleles with platelet versus hepatic source questions.
What F5 mouse models are available?
ingenious targeting laboratory offers 2 distinct F5 (F5) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
F5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
F5 allele types
Knockout, conditional, knockin, humanized, and related paths for F5 (human F5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a F5 mouse model?
We have 2 F5 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About F5 Mouse Model Types
A F5 knockout mouse has the F5 gene permanently inactivated, enabling loss of function studies. A F5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of F5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for F5 organized by modification type. Each URL is indexable and matches common search patterns.