Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · EMBRYO · DEVELOPING
F9 Knockout, Xenograft-Applicable mouse models
Browse 3 F9 mouse models including knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as F9 knockout mouse, F9 xenograft-applicable mouse. Request a quote within 24 hours.
Why model F9
F9, ortholog of human F9, encodes coagulation factor IX and sits on the X chromosome, making hemizygous males the natural genetic configuration for hemophilia B modeling. The vitamin K dependent zymogen presents a Gla domain, two EGF modules, an activation peptide, and a protease domain; cleavage by factor XIa or by the tissue factor and factor VIIa complex yields factor IXa, which assembles with factor VIIIa on activated platelet membranes into intrinsic tenase to activate factor X, with the EGF1 and Gla surfaces mediating cofactor and membrane contacts. Mouse nulls reproduce the coagulopathy and remain the standard preclinical hemophilia B platform. Two allele designs answer different questions: patient-specific missense knockins interrogate residual activity, inhibitor development, and immune tolerance, whereas the hyperfunctional Padua substitution at Arg338 underpins gene therapy potency studies. Humanized F9 knockins are required when human factor IX directed antibody, Fc or albumin fusion pharmacokinetics, or mimetic bispecific activity is the readout.
What F9 mouse models are available?
ingenious targeting laboratory offers 3 distinct F9 (F9) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
F9 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
F9 allele types
Knockout, conditional, knockin, humanized, and related paths for F9 (human F9). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available F9 catalog models
3 F9 lines with QC documentation and technical support.
- Order
F9-KO
KOKO, Disease Model
The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.KO 18046）carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.KO 200607) carrying the exon 1-8 deletion.
Embryo CryopreservedKO 18046 - Order
F9-KO(2)
KOKO, Disease Model
F9-KO(2) mice (Stock No.KO 200607）carry a knockout allele derived from the targeted deletion of exon 1-8. While F9-KO mice (Stock No.KO 18046) carrying the exon 8 deletion.
LiveKO 200607 - Order
F9-KO/hPROCR
XAKO, Target-Humanized
The hPROCR(HU 240012) was crossed with F9-KO(2)(KO 200607) to generate F9-KO/hPROCR mice.
Not DevelopedXA 242801
Looking for a F9 mouse model?
We have 3 F9 models in stock — including Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About F9 Mouse Model Types
A F9 knockout mouse has the F9 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for F9 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the F9 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.