Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
EMBRYO · IN PRODUCTION
Fbp1 Conditional Knockout, Knockout mouse models
Browse 2 Fbp1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fbp1 conditional knockout mouse, Fbp1 knockout mouse. Request a quote within 24 hours.
Why model Fbp1
Fbp1 encodes the mouse ortholog of human FBP1, the liver and kidney fructose-1,6-bisphosphatase that hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate and, with Pck1 and G6pc1, sets gluconeogenic flux. The tetrameric enzyme is allosterically inhibited by AMP at a site distinct from the active site and synergistically by fructose-2,6-bisphosphate, making it the node where cellular energy charge and insulin signaling veto hepatic glucose output. Human FBP1 deficiency presents as fasting hypoglycemia with lactic acidosis and ketosis, typically unmasked by intercurrent illness rather than at baseline. Allele planning follows that logic: a hepatocyte conditional null with Alb-Cre interrogates fasting glucose production directly, AMP-site mutant knockins create a constitutively active enzyme to probe flux control, and humanization supports variant and inhibitor studies. Because Fbp2 covers skeletal muscle, a liver-restricted null leaves systemic FBPase activity intact. Pair alleles with fasting and pyruvate tolerance testing plus glycerol tracing rather than steady-state glycemia alone.
What Fbp1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fbp1 (FBP1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fbp1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fbp1 allele types
Knockout, conditional, knockin, humanized, and related paths for Fbp1 (human FBP1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fbp1 catalog models
2 Fbp1 lines with QC documentation and technical support. Fbp1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Fbp1-Flox
CKOCKO
These mice carry loxP sites flanking exon2 of Fbp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Fbp1 gene.
In production — inquireCKO 260764 - Order
Fbp1-KO
KOKO
Exon 2 of Fbp1 gene was deleted to generate Fbp1 knockout mice.
Embryo CryopreservedKO 190796
Looking for a Fbp1 mouse model?
We have 2 Fbp1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fbp1 Mouse Model Types
A Fbp1 knockout mouse has the Fbp1 gene permanently inactivated, enabling loss of function studies. A Fbp1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fbp1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fbp1 organized by modification type. Each URL is indexable and matches common search patterns.
Related Gene Targets
Breed this line with ingenious targeting laboratory
Send the Fbp1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.