Conventional / global / constitutive KO
●2 Models Available
Fbp2 Conditional Knockout, Knockout mouse models
Browse 2 Fbp2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fbp2 conditional knockout mouse, Fbp2 knockout mouse. Contact us for availability and fast turnaround.
Why model Fbp2
The muscle-predominant fructose-1,6-bisphosphatase is encoded by Fbp2, ortholog of human FBP2, which hydrolyzes fructose-1,6-bisphosphate during glyconeogenesis, allowing lactate carbon to be resynthesized into glycogen after intense contraction. The Fbp2 protein is markedly more AMP sensitive than the liver isoform and additionally associates with aldolase, mitochondria and nuclei, where it has been reported to stabilize mitochondrial membrane potential and restrain apoptosis, activities separable from gluconeogenic catalysis. The allele fork therefore matters: a conditional null in skeletal muscle or cardiomyocytes tests glycogen resynthesis and recovery kinetics, whereas point mutants that break either the AMP site or the aldolase interaction dissociate catalysis from the reported protective role. Because Fbp1 covers liver and kidney, whole-body glucose homeostasis will often look normal, so avoid systemic glycemia as a primary readout. Instead match allele to muscle glycogen repletion, mitochondrial respirometry and postexercise recovery, using tamoxifen-inducible Cre to bypass developmental adaptation.
What Fbp2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fbp2 (FBP2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fbp2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fbp2 allele types
Knockout, conditional, knockin, humanized, and related paths for Fbp2 (human FBP2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fbp2 catalog models
2 Fbp2 lines with QC documentation and technical support. Fbp2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fbp2 mouse model?
We have 2 Fbp2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fbp2 Mouse Model Types
A Fbp2 knockout mouse has the Fbp2 gene permanently inactivated, enabling loss of function studies. A Fbp2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fbp2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fbp2 organized by modification type. Each URL is indexable and matches common search patterns.