Fgf13 Knockout mouse models
Fgf13 (FGF13) contributes to FGF receptor tyrosine kinase signaling in morphogenesis and repair. Global knockout often ends before adult questions can be asked, so conditional timing is the default commercial request. Hypomorphic knockins can mimic human FGF13 dosage syndromes better than complete nulls when partial function is the clinical picture. Antibody programs against human FGF13 should prioritize humanized Fgf13 once developmental viability of the conditional plan is proven. If embryogenesis collapses the cohort, do not force a conventional KO for an adult endpoint at Fgf13. Tissue restricted Cre drivers isolate whether Fgf13 acts from epithelium, mesenchyme, or a discrete organizing center during organogenesis. Patterning genes reward spatial and temporal control more than blunt systemic deletion, and quotes should say that clearly.
Whole body loss of Fgf13 gives the clearest readout when the question is whether the gene is required at all. Follow up tissue work may still move to a conditional allele if lethality or compensation appears.
Catalog table
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
A conventional knockout answers whether the gene is required broadly. When liver is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Fgf13-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 210337 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
A conventional knockout answers whether the gene is required broadly. When liver is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Fgf13 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Fgf13 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
Is Fgf13 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Fgf13 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.
Do you ship live Fgf13 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Fgf13?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.