Conventional / global / constitutive KO
●3 Models Available
Fus Conditional Knockout, Knockin mouse models
Browse 3 Fus mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fus conditional knockout mouse, Fus knockin mouse. Request a quote within 24 hours.
Why model Fus
Fus encodes the FET family RNA-binding protein FUS, ortholog of human FUS, organized as an N-terminal QGSY-rich low complexity prion-like domain, an RGG-flanked RRM, a zinc finger, and a C-terminal PY nuclear localization signal recognized by Transportin-1; it binds nascent transcripts, regulates splicing and transcription elongation, and undergoes liquid-liquid phase separation that is normally restrained by nuclear import and arginine methylation. Amyotrophic lateral sclerosis mutations cluster in the PY-NLS, notably R521C and P525L, weakening Transportin binding and driving cytoplasmic mislocalization, stress granule partitioning and progressive aggregation, a toxic gain-of-function mechanism distinct from the nuclear loss seen in FTLD-FUS. Because constitutive nulls show perinatal lethality on C57BL/6 backgrounds and only partial recovery on outbred backgrounds, NLS-mutant knockins and Δ14 frameshift alleles are the designs that reproduce motor neuron degeneration at endogenous expression. Ewsr1 and Taf15 share domain architecture and buffer nuclear functions, so score cytoplasmic mislocalization directly.
What Fus mouse models are available?
ingenious targeting laboratory offers 3 distinct Fus (FUS) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fus model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fus allele types
Knockout, conditional, knockin, humanized, and related paths for Fus (human FUS). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fus catalog models
3 Fus lines with QC documentation and technical support. Fus floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Fus (FUS) from ITL supported projects.
- AIM2 inflammasome mediates apoptotic and pyroptotic death in the cerebellum following chronic hypoperfusionPoh L, Razak S, Lim HM, Lai MKP, Chen CL, Lim LHK, Arumugam TV, Fann DY. (2021). Exp Neurol346: 113856
- FGF8 acts as a classic diffusible morphogen to pattern the neocortex.Toyoda R, Assimacopoulos S, Wilcoxon J, Taylor A, Feldman P, Suzuki-Hirano A, Shimogori T, Grove EA. (2010). Development137: 3439-3448
- Mitochondrial fusion protects against neurodegeneration in the cerebellum.Chen H, McCaffery JM, Chan DC. (2007). Cell130: 548-562
Looking for a Fus mouse model?
We have 3 Fus models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fus Mouse Model Types
A Fus conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fus, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Fus knockin models carry a precisely inserted sequence at the Fus locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Fus organized by modification type. Each URL is indexable and matches common search patterns.