Conventional / global / constitutive KO
●2 Models Available
G6pc Conditional Knockout, Knockout mouse models
Browse 2 G6pc mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as G6pc conditional knockout mouse, G6pc knockout mouse. Contact us for availability and fast turnaround.
Why model G6pc
Encoding the catalytic subunit of glucose-6-phosphatase, G6pc is the mouse ortholog of human G6PC and completes both gluconeogenesis and glycogenolysis by hydrolyzing glucose-6-phosphate within the endoplasmic reticulum lumen, working obligately with the Slc37a4 transporter that delivers substrate across the membrane. Loss-of-function mutations cause glycogen storage disease type Ia, with fasting hypoglycemia, hepatomegaly, lactic acidemia, and nephropathy, and whole-body nulls in mouse suffer severe neonatal hypoglycemia and high early mortality, so survivable studies generally require a floxed allele deleted postnatally in liver or kidney using Alb-Cre or AAV8-delivered Cre. Patient-mutation knockins such as R83C preserve residual biology for enzyme-correction studies, whereas humanization of the locus is the design that supports gene therapy, base editing, and mRNA replacement testing against the actual human sequence. Note that G6pc2 and G6pc3 do not substitute for hepatic output, so redundancy is not a rescue here; match allele and Cre timing to the metabolic endpoint you intend to measure.
What G6pc mouse models are available?
ingenious targeting laboratory offers 2 distinct G6pc (G6PC) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
G6pc model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
G6pc allele types
Knockout, conditional, knockin, humanized, and related paths for G6pc (human G6PC). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available G6pc catalog models
2 G6pc lines with QC documentation and technical support. G6pc floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a G6pc mouse model?
We have 2 G6pc models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About G6pc Mouse Model Types
A G6pc knockout mouse has the G6pc gene permanently inactivated, enabling loss of function studies. A G6pc conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of G6pc, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for G6pc organized by modification type. Each URL is indexable and matches common search patterns.