Conventional / global / constitutive KO
●3 Models Available
Gckr Conditional Knockout, Knockout mouse models
Browse 3 Gckr mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Gckr conditional knockout mouse, Gckr knockout mouse. Contact us for availability and fast turnaround.
Why model Gckr
Gckr, the mouse ortholog of human GCKR, encodes glucokinase regulatory protein, a sugar isomerase fold protein that binds hepatic glucokinase and sequesters it in the nucleus, releasing it to the cytosol when fructose-1-phosphate rises and retaining it when fructose-6-phosphate accumulates, so hepatic glucose phosphorylation reports fructose and glycolytic intermediates rather than glucose alone. The common human P446L variant weakens this restraint, lowering fasting glucose and insulin while raising triglycerides, one of the clearest examples of an allele with divergent cardiometabolic consequences. That biology argues for a humanized knockin carrying the P446L substitution when the goal is to reproduce the human tradeoff, whereas a hepatocyte conditional null models complete loss of glucokinase sequestration and unrestrained lipogenic flux. No paralog substitutes for GKRP, so residual regulation depends on glucokinase expression itself. Match allele to endpoint, whether glucokinase translocation imaging, de novo lipogenesis tracing, or fructose challenge with paired lipid and glucose profiling.
What Gckr mouse models are available?
ingenious targeting laboratory offers 3 distinct Gckr (GCKR) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gckr model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gckr allele types
Knockout, conditional, knockin, humanized, and related paths for Gckr (human GCKR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gckr catalog models
3 Gckr lines with QC documentation and technical support. Gckr floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gckr mouse model?
We have 3 Gckr models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gckr Mouse Model Types
A Gckr knockout mouse has the Gckr gene permanently inactivated, enabling loss of function studies. A Gckr conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gckr, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gckr organized by modification type. Each URL is indexable and matches common search patterns.