Conventional / global / constitutive KO
●2 Models Available
Gck Conditional Knockout, Knockout mouse models
Browse 2 Gck mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Gck conditional knockout mouse, Gck knockout mouse. Contact us for availability and fast turnaround.
Why model Gck
Glucokinase, encoded by Gck as the mouse ortholog of human GCK, is hexokinase IV, a monomeric enzyme with low glucose affinity, sigmoidal kinetics, no product inhibition by glucose-6-phosphate, and an allosteric activator site distinct from the catalytic cleft, properties that let it act as the glucose sensor of pancreatic beta cells and hepatocytes, where Gckr-encoded regulatory protein sequesters it in the nucleus until fructose-1-phosphate releases it. Heterozygous inactivating mutations produce GCK-MODY with a raised glucose threshold for insulin release, while activating mutations cause congenital hyperinsulinism, and homozygous null mice die perinatally from severe diabetes, so heterozygous or tissue-restricted conditional alleles are the workable designs. Beta-cell deletion using Ins1-Cre interrogates secretion thresholds, hepatocyte deletion using Alb-Cre interrogates glucose disposal and glycogen synthesis, activating knockins model hyperinsulinism, and humanization enables glucokinase activator pharmacology. Hexokinases 1 through 3 have far lower Km and cannot reconstitute sensing, so compensation is not a confound.
What Gck mouse models are available?
ingenious targeting laboratory offers 2 distinct Gck (GCK) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gck model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gck allele types
Knockout, conditional, knockin, humanized, and related paths for Gck (human GCK). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gck catalog models
2 Gck lines with QC documentation and technical support. Gck floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gck mouse model?
We have 2 Gck models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gck Mouse Model Types
A Gck knockout mouse has the Gck gene permanently inactivated, enabling loss of function studies. A Gck conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gck, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gck organized by modification type. Each URL is indexable and matches common search patterns.