Conventional / global / constitutive KO
●4 Models Available
Gsdmd Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Gsdmd mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gsdmd conditional knockout mouse, Gsdmd knockin mouse, Gsdmd knockout mouse. Request a quote within 24 hours.
Why model Gsdmd
Gsdmd is the mouse ortholog of human GSDMD and encodes gasdermin D, a two-domain protein in which an autoinhibitory C-terminal domain restrains an N-terminal pore-forming module. Inflammatory caspase-1 and caspase-11, and in some settings caspase-8 or neutrophil elastase, cleave the interdomain linker at Asp276 in mouse, liberating the p30 fragment that binds acidic membrane lipids, oligomerizes into large beta-barrel pores, and provides the conduit for mature interleukin 1 beta and interleukin 18 export before NINJ1 dependent membrane rupture completes pyroptosis. Allele choice maps onto mechanism directly: a conditional null removes both cytokine release and lytic death, a D276A noncleavable knockin isolates processing from expression, and pore-dead point mutants separate lysis from unconventional secretion. Gsdme and the Gsdma cluster execute overlapping lytic programs downstream of caspase-3 or bacterial proteases, so pyroptosis-resistant phenotypes may require compound alleles, and myeloid restricted Cre lines assign the death to the intended lineage.
What Gsdmd mouse models are available?
ingenious targeting laboratory offers 4 distinct Gsdmd (GSDMD) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gsdmd model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gsdmd allele types
Knockout, conditional, knockin, humanized, and related paths for Gsdmd (human GSDMD). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gsdmd catalog models
4 Gsdmd lines with QC documentation and technical support. Gsdmd floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gsdmd mouse model?
We have 4 Gsdmd models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gsdmd Mouse Model Types
A Gsdmd knockout mouse has the Gsdmd gene permanently inactivated, enabling loss of function studies. A Gsdmd conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gsdmd, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Gsdmd knockin models carry a precisely inserted sequence at the Gsdmd locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Gsdmd organized by modification type. Each URL is indexable and matches common search patterns.