Conventional / global / constitutive KO
●2 Models Available
Gsk3b Conditional Knockout, Knockout mouse models
Browse 2 Gsk3b mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Gsk3b conditional knockout mouse, Gsk3b knockout mouse. Contact us for availability and fast turnaround.
Why model Gsk3b
Encoding a constitutively active serine and threonine kinase that prefers substrates pre-phosphorylated four residues carboxy-terminal to its site, Gsk3b is the mouse ortholog of human GSK3B and is inhibited by Akt phosphorylation of Ser9 as well as by Wnt-driven sequestration; within the Axin and Apc destruction complex it phosphorylates beta-catenin at Ser33, Ser37, and Thr41 to license betaTrCP-mediated degradation, and it also targets tau, Snai1, Mcl1, Nfatc, and glycogen synthase. Homozygous nulls die at mid-gestation with hepatocyte apoptosis reflecting defective NF-kB survival signaling, so conditional deletion is standard, while a Ser9-to-alanine knockin creates an Akt-resistant kinase that tests whether inhibitory phosphorylation is required in vivo and a kinase-dead allele distinguishes scaffolding from catalysis. Critically, Gsk3a is a genuine paralog with overlapping substrate specificity, and many phenotypes emerge only in double conditional animals, so plan the compound cross and driver together with the primary flox.
What Gsk3b mouse models are available?
ingenious targeting laboratory offers 2 distinct Gsk3b (GSK3B) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gsk3b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gsk3b allele types
Knockout, conditional, knockin, humanized, and related paths for Gsk3b (human GSK3B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gsk3b catalog models
2 Gsk3b lines with QC documentation and technical support. Gsk3b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gsk3b mouse model?
We have 2 Gsk3b models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gsk3b Mouse Model Types
A Gsk3b knockout mouse has the Gsk3b gene permanently inactivated, enabling loss of function studies. A Gsk3b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gsk3b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gsk3b organized by modification type. Each URL is indexable and matches common search patterns.