Conventional / global / constitutive KO
●1 Model Available
Hist1h4i Conditional Knockout mouse model
Browse 1 Hist1h4i mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Hist1h4i
Chaperone-mediated deposition determines where the histone H4 encoded by Hist1h4i, ortholog of human HIST1H4I, ends up in chromatin. The H3 to H4 dimer is escorted by ASF1A or ASF1B, which blocks premature tetramerization, then transferred to the CAF-1 heterotrimer of CHAF1A, CHAF1B, and RBBP4 for PCNA-coupled assembly behind the replication fork, or to HIRA for replication-independent gap filling with the H3.3 variant. Parental histone recycling through MCM2 and POLE3 with POLE4 preserves marks across the fork and underlies epigenetic inheritance. This locus is a standard replication-dependent cluster gene with an S phase restricted, stem-loop terminated transcript. Its invariant protein product is shared with every other H4 gene and identical to human H4, so single deletion is silent and humanization is not applicable. Use dominant tail knockins to interrogate chaperone recognition, and time Cre activity to an actively cycling population.
What Hist1h4i mouse models are available?
ingenious targeting laboratory offers 1 distinct Hist1h4i (HIST1H4I) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hist1h4i model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hist1h4i allele types
Knockout, conditional, knockin, humanized, and related paths for Hist1h4i (human HIST1H4I). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hist1h4i catalog models
1 Hist1h4i line with QC documentation and technical support. Hist1h4i floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Hist1h4i-Flox
Conditional KnockoutKO/CKO mice
embryo cryopreservationCKO 205092
Looking for a Hist1h4i mouse model?
We have 1 Hist1h4i model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hist1h4i Mouse Model Types
A Hist1h4i conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hist1h4i, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hist1h4i organized by modification type. Each URL is indexable and matches common search patterns.