Conventional / global / constitutive KO
●2 Models Available
Hkdc1 Conditional Knockout, Knockout mouse models
Browse 2 Hkdc1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Hkdc1 conditional knockout mouse, Hkdc1 knockout mouse. Contact us for availability and fast turnaround.
Why model Hkdc1
Hkdc1 encodes the mouse ortholog of human HKDC1, the fifth hexokinase family member, which retains hexokinase domain architecture but exhibits low glucose-phosphorylating activity and is expressed in liver, gut and placenta rather than in classic glycolytic tissues. Human variants near HKDC1 associate with maternal glucose levels during pregnancy and with gestational glucose handling, and mouse work implicates the protein in hepatic glucose tolerance, lipid handling and association with mitochondria and lipid droplets, suggesting a regulatory rather than high-flux catalytic role. Because the physiology is pregnancy and liver centered, allele choice should match: a whole-body null clarifies gestational glucose phenotypes, a hepatocyte conditional null with Alb-Cre separates liver-autonomous effects from placental contributions, and humanized knockins permit interrogation of specific human coding and noncoding variants. Hk1 and Hk2 supply the bulk of hexokinase activity in most tissues, so avoid total activity assays as a readout. Center endpoints on pregnancy glucose tolerance, hepatic lipid quantification and tracer-based flux.
What Hkdc1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Hkdc1 (HKDC1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hkdc1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hkdc1 allele types
Knockout, conditional, knockin, humanized, and related paths for Hkdc1 (human HKDC1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hkdc1 catalog models
2 Hkdc1 lines with QC documentation and technical support. Hkdc1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Hkdc1 mouse model?
We have 2 Hkdc1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hkdc1 Mouse Model Types
A Hkdc1 knockout mouse has the Hkdc1 gene permanently inactivated, enabling loss of function studies. A Hkdc1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hkdc1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hkdc1 organized by modification type. Each URL is indexable and matches common search patterns.