Conventional / global / constitutive KO
●2 Models Available
Hnrnpa1 Conditional Knockout, Knockout mouse models
Browse 2 Hnrnpa1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Hnrnpa1 conditional knockout mouse, Hnrnpa1 knockout mouse. Request a quote within 24 hours.
Why model Hnrnpa1
Hnrnpa1, the mouse ortholog of human HNRNPA1, encodes heterogeneous nuclear ribonucleoprotein A1, an abundant RNA-binding protein with tandem RRM domains and a carboxy-terminal low-complexity prion-like domain that drives reversible liquid-liquid phase separation. A1 antagonizes SR proteins to control alternative splice site selection, participates in mRNA export and internal ribosome entry site-dependent translation, and shuttles through the M9 signal recognized by transportin-1. Disease mutations in the prion-like domain, notably D262V, accelerate fibrillization and cause multisystem proteinopathy with inclusion body myopathy, Paget disease of bone, and ALS, so knockin alleles preserve the gain-of-toxic-assembly mechanism that deletion cannot reproduce. Because A1 is broadly required for splicing homeostasis, conditional floxed alleles paired with neuron- or muscle-restricted Cre drivers are safer than germline deletion for adult phenotyping. The paralog Hnrnpa1l2 and the related Hnrnpa2b1 overlap substantially in target repertoire, so score splicing outcomes transcriptome-wide instead of assuming loss produces a clean null state.
What Hnrnpa1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Hnrnpa1 (HNRNPA1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hnrnpa1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hnrnpa1 allele types
Knockout, conditional, knockin, humanized, and related paths for Hnrnpa1 (human HNRNPA1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hnrnpa1 catalog models
2 Hnrnpa1 lines with QC documentation and technical support. Hnrnpa1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Hnrnpa1 mouse model?
We have 2 Hnrnpa1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hnrnpa1 Mouse Model Types
A Hnrnpa1 knockout mouse has the Hnrnpa1 gene permanently inactivated, enabling loss of function studies. A Hnrnpa1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hnrnpa1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hnrnpa1 organized by modification type. Each URL is indexable and matches common search patterns.