Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM
Hnrnpa1 Conditional Knockout, Knockout mouse models
Browse 2 Hnrnpa1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Hnrnpa1 conditional knockout mouse, Hnrnpa1 knockout mouse. Contact us for availability and fast turnaround.
Why model Hnrnpa1
Hnrnpa1, the mouse ortholog of human HNRNPA1, encodes heterogeneous nuclear ribonucleoprotein A1, an abundant RNA-binding protein with tandem RRM domains and a carboxy-terminal low-complexity prion-like domain that drives reversible liquid-liquid phase separation. A1 antagonizes SR proteins to control alternative splice site selection, participates in mRNA export and internal ribosome entry site-dependent translation, and shuttles through the M9 signal recognized by transportin-1. Disease mutations in the prion-like domain, notably D262V, accelerate fibrillization and cause multisystem proteinopathy with inclusion body myopathy, Paget disease of bone, and ALS, so knockin alleles preserve the gain-of-toxic-assembly mechanism that deletion cannot reproduce. Because A1 is broadly required for splicing homeostasis, conditional floxed alleles paired with neuron- or muscle-restricted Cre drivers are safer than germline deletion for adult phenotyping. The paralog Hnrnpa1l2 and the related Hnrnpa2b1 overlap substantially in target repertoire, so score splicing outcomes transcriptome-wide instead of assuming loss produces a clean null state.
What Hnrnpa1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Hnrnpa1 (HNRNPA1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hnrnpa1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hnrnpa1 allele types
Knockout, conditional, knockin, humanized, and related paths for Hnrnpa1 (human HNRNPA1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hnrnpa1 catalog models
2 Hnrnpa1 lines with QC documentation and technical support. Hnrnpa1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Hnrnpa1-Flox
CKOCKO
These mice carry loxP sites flanking exon 2-7 of Hnrnpa1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hnrnpa1 gene.
Sperm CryopreservedCKO 252121 - Order
Hnrnpa1-KO
KOKO
The exon 2-7 of Hnrnpa1 gene was deleted to generate Hnrnpa1 knockout mouse.
Sperm CryopreservedKO 253500
Looking for a Hnrnpa1 mouse model?
We have 2 Hnrnpa1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hnrnpa1 Mouse Model Types
A Hnrnpa1 knockout mouse has the Hnrnpa1 gene permanently inactivated, enabling loss of function studies. A Hnrnpa1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hnrnpa1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hnrnpa1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Hnrnpa1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.