Conventional / global / constitutive KO
●2 Models Available
Hnrnpa2b1 Conditional Knockout, Knockout mouse models
Browse 2 Hnrnpa2b1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Hnrnpa2b1 conditional knockout mouse, Hnrnpa2b1 knockout mouse. Contact us for availability and fast turnaround.
Why model Hnrnpa2b1
Alternative splicing of exon 2 in Hnrnpa2b1, the mouse ortholog of human HNRNPA2B1, produces the A2 and B1 isoforms of a nuclear RNA-binding protein that pairs two RRM domains with a glycine-rich prion-like domain. A2 binds the A2 response element to transport myelin basic protein transcripts along oligodendrocyte processes, functions as a nuclear reader of N6-methyladenosine that shapes splicing and primary microRNA processing, and phase separates into transport granules whose material state is tuned by arginine methylation. Prion-like domain mutations such as D290V steepen the fibrillization trajectory and cause multisystem proteinopathy with ALS, so disease knockins capture the aggregation mechanism that deletion does not. Conditional alleles are preferable given the broad requirement for this protein in splicing and myelination, and pairing with Cnp-Cre or neuronal drivers localizes the phenotype. Hnrnpa1 shares many binding sites, so compound genetics and transcriptome-wide splicing readouts should be planned alongside the primary allele.
What Hnrnpa2b1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Hnrnpa2b1 (HNRNPA2B1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hnrnpa2b1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hnrnpa2b1 allele types
Knockout, conditional, knockin, humanized, and related paths for Hnrnpa2b1 (human HNRNPA2B1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hnrnpa2b1 catalog models
2 Hnrnpa2b1 lines with QC documentation and technical support. Hnrnpa2b1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Hnrnpa2b1 mouse model?
We have 2 Hnrnpa2b1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hnrnpa2b1 Mouse Model Types
A Hnrnpa2b1 knockout mouse has the Hnrnpa2b1 gene permanently inactivated, enabling loss of function studies. A Hnrnpa2b1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hnrnpa2b1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hnrnpa2b1 organized by modification type. Each URL is indexable and matches common search patterns.