Conventional / global / constitutive KO
●1 Model Available
Hras Knockout mouse model
Browse 1 Hras mouse model including knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Hras
Hras, ortholog of human HRAS, encodes a small GTPase that cycles between GDP and GTP states under Sos1-family exchange factors and p120 and Nf1 GAPs, engaging Raf kinases, PI3K, and RalGDS when loaded; its distinguishing feature is the hypervariable carboxy-terminal region, which carries both farnesylation and dual palmitoylation and therefore traffics through the Golgi to cholesterol-rich plasma membrane microdomains rather than the disordered regions favored by Kras. Somatic G12V and Q61L substitutions occur in bladder and head and neck carcinoma, while germline G12S and G13D cause Costello syndrome, giving three distinct allele classes: a Lox-Stop-Lox oncogenic knockin for tumor initiation, an endogenous RASopathy point mutation for developmental and cardiac phenotypes, and humanization for isoform-selective inhibitor testing. Hras nulls are viable because Kras carries the essential load, so single-gene deletion is rarely informative, and compound Hras and Nras alleles combined with tissue-restricted Cre give interpretable results.
What Hras mouse models are available?
ingenious targeting laboratory offers 1 distinct Hras (HRAS) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hras model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hras allele types
Knockout, conditional, knockin, humanized, and related paths for Hras (human HRAS). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hras catalog models
1 Hras line with QC documentation and technical support.
- Order
Hras-KO
KnockoutKO/CKO mice
embryo cryopreservationKO 191092
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Hras (HRAS) from ITL supported projects.
- Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironmentMa J, Al Moussawi K, Lou H, Chan HF, Wang Y, Chadwick J, Phetsouphanh C, Slee EA, Zhong S, Leissing TM, Roth A, Qin X, Chen S, Yin J, Ratnayaka I, Hu Y, Louphrasitthiphol P, Taylor L, Bettencourt PJG, Muers M, Greaves DR, McShane H, Goldin R, Soilleux EJ, Coleman ML, Ratcliffe PJ, Lu X. (2024). Proc Natl Acad Sci U S A 121(10): e2309957121
- The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice.Bacchelli C, Buckland KF, Buckridge S, Salzer U, Schneider P, Thrasher AJ, Gaspar HB. (2011). J Allergy Clin Immunol127: 1253-1259 e1213
Looking for a Hras mouse model?
We have 1 Hras model available — including Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hras Mouse Model Types
A Hras knockout mouse has the Hras gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Hras organized by modification type. Each URL is indexable and matches common search patterns.