Conventional / global / constitutive KO
●2 Models Available
Ifna1 Conditional Knockout, Knockout mouse models
Browse 2 Ifna1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ifna1 conditional knockout mouse, Ifna1 knockout mouse. Contact us for availability and fast turnaround.
Why model Ifna1
Ifna1 sits within a tandem cluster of roughly fourteen intact interferon alpha genes on mouse chromosome 4 and corresponds to human IFNA1, encoding a single helical type I interferon that engages the shared IFNAR1 and IFNAR2 heterodimer, activates JAK1 and TYK2, and assembles the ISGF3 complex of STAT1, STAT2, and IRF9 on interferon stimulated response elements. Subtype identity tunes receptor affinity and therefore the balance of antiviral versus antiproliferative output rather than creating unique signaling, which has a hard consequence for allele design: deleting Ifna1 alone is almost always uninformative because the remaining subtypes are coregulated by IRF7 and compensate fully. Productive designs instead remove the entire cluster, target Ifnar1, or install a reporter at Ifna1 to time and localize subtype induction in vivo. When human interferon pharmacology is the endpoint, species restricted receptor engagement makes humanization of the ligand or receptor pair, not a subtype knockout, the appropriate allele.
What Ifna1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ifna1 (IFNA1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ifna1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ifna1 allele types
Knockout, conditional, knockin, humanized, and related paths for Ifna1 (human IFNA1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ifna1 catalog models
2 Ifna1 lines with QC documentation and technical support. Ifna1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ifna1 mouse model?
We have 2 Ifna1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ifna1 Mouse Model Types
A Ifna1 knockout mouse has the Ifna1 gene permanently inactivated, enabling loss of function studies. A Ifna1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ifna1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ifna1 organized by modification type. Each URL is indexable and matches common search patterns.