Conventional / global / constitutive KO
●2 Models Available
Ifnb1 Conditional Knockout, Knockout mouse models
Browse 2 Ifnb1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ifnb1 conditional knockout mouse, Ifnb1 knockout mouse. Contact us for availability and fast turnaround.
Why model Ifnb1
Unlike the multigene alpha cluster, Ifnb1 is single copy, which makes this mouse ortholog of human IFNB1 the rate limiting first wave ligand of the type I interferon system. Transcription is driven by IRF3 dimers phosphorylated at Ser386 and Ser396 by TBK1 downstream of cGAS and STING, MAVS, or TRIF, cooperating with NF-kB and ATF2 with c-Jun on the compact enhanceosome, and the resulting autocrine IFNAR signal induces IRF7 to amplify the alpha subtypes. That architecture means a conditional Ifnb1 null truncates the initiating signal without touching amplification, a knockin reporter such as luciferase times and localizes sensing in vivo, and Ifnar1 deletion instead removes all downstream response. Because human IFNB1 does not productively engage murine IFNAR, humanization is required for biologic pharmacology. Cell type assignment matters more here than for most cytokines, since stromal, dendritic, and epithelial sources differ, so pair the flox with lineage restricted Cre drivers.
What Ifnb1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ifnb1 (IFNB1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ifnb1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ifnb1 allele types
Knockout, conditional, knockin, humanized, and related paths for Ifnb1 (human IFNB1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ifnb1 catalog models
2 Ifnb1 lines with QC documentation and technical support. Ifnb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ifnb1 mouse model?
We have 2 Ifnb1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ifnb1 Mouse Model Types
A Ifnb1 knockout mouse has the Ifnb1 gene permanently inactivated, enabling loss of function studies. A Ifnb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ifnb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ifnb1 organized by modification type. Each URL is indexable and matches common search patterns.