Conventional / global / constitutive KO
●3 Models Available
Igf1r Conditional Knockout, Knockout mouse models
Browse 3 Igf1r mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Igf1r conditional knockout mouse, Igf1r knockout mouse. Contact us for availability and fast turnaround.
Why model Igf1r
The mouse Igf1r locus, ortholog of human IGF1R, specifies a disulfide-linked alpha2beta2 receptor tyrosine kinase that binds IGF-1 and IGF-2, autophosphorylates activation loop, juxtamembrane and C-terminal tyrosines, and recruits IRS1, IRS2 and SHC to drive PI3K to AKT and ERK output, and it also forms hybrid receptors with the insulin receptor that blur ligand specificity in tissues expressing both. Null mice are severely growth retarded and die neonatally of respiratory failure, so viable interrogation requires conditional alleles, with muscle, adipose, neuronal or endothelial Cre lines separating growth, metabolic and vascular contributions and inducible Cre avoiding developmental confounds. Kinase-dead and epitope-humanized knockins address different questions, the former testing scaffold versus catalytic function and the latter enabling preclinical evaluation of IGF1R-directed antibodies and inhibitors whose selectivity against the insulin receptor is the key liability. Because Insr forms hybrids and signals to the same effectors, plan compound Igf1r and Insr alleles before interpreting insulin sensitivity endpoints.
What Igf1r mouse models are available?
ingenious targeting laboratory offers 3 distinct Igf1r (IGF1R) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Igf1r model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Igf1r allele types
Knockout, conditional, knockin, humanized, and related paths for Igf1r (human IGF1R). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Igf1r catalog models
3 Igf1r lines with QC documentation and technical support. Igf1r floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Igf1r mouse model?
We have 3 Igf1r models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Igf1r Mouse Model Types
A Igf1r knockout mouse has the Igf1r gene permanently inactivated, enabling loss of function studies. A Igf1r conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Igf1r, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Igf1r organized by modification type. Each URL is indexable and matches common search patterns.