Conventional / global / constitutive KO
●2 Models Available
Kcnj10 Conditional Knockout, Knockout mouse models
Browse 2 Kcnj10 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Kcnj10 conditional knockout mouse, Kcnj10 knockout mouse. Request a quote within 24 hours.
Why model Kcnj10
Kcnj10, the mouse ortholog of human KCNJ10, encodes Kir4.1, the principal inwardly rectifying potassium channel of astrocytes, Bergmann glia, oligodendrocytes, and retinal Muller cells, where it clamps the glial membrane near the potassium equilibrium potential and performs spatial buffering of extracellular potassium released during neuronal firing. Kir4.1 functions as a homotetramer or as an obligate partner in Kir4.1/Kir5.1 heteromers with the Kcnj16 product, which confers steep intracellular pH sensitivity, and it also operates in the distal convoluted tubule and stria vascularis, coupling to the sodium pump and to chloride handling. Biallelic human mutations cause SeSAME/EAST syndrome with seizures, ataxia, sensorineural deafness, and renal salt wasting, and constitutive nulls die in the early postnatal period with hypomyelination and severe motor impairment, so glia-restricted conditional deletion using Gfap-Cre or Aldh1l1-CreER is required for adult work. No other glial Kir substitutes effectively, so match allele to whether the endpoint is potassium clearance, seizure threshold, or renal electrolyte handling.
What Kcnj10 mouse models are available?
ingenious targeting laboratory offers 2 distinct Kcnj10 (KCNJ10) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kcnj10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
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Kcnj10 allele types
Knockout, conditional, knockin, humanized, and related paths for Kcnj10 (human KCNJ10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kcnj10 catalog models
2 Kcnj10 lines with QC documentation and technical support. Kcnj10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kcnj10 mouse model?
We have 2 Kcnj10 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kcnj10 Mouse Model Types
A Kcnj10 knockout mouse has the Kcnj10 gene permanently inactivated, enabling loss of function studies. A Kcnj10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kcnj10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kcnj10 organized by modification type. Each URL is indexable and matches common search patterns.