Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
SPERM · EMBRYO
Kcnj13 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Kcnj13 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Kcnj13 conditional knockout mouse, Kcnj13 knockin mouse, Kcnj13 knockout mouse. Contact us for availability and fast turnaround.
Why model Kcnj13
Kcnj13, the mouse ortholog of human KCNJ13, encodes Kir7.1, an atypical inward rectifier with unusually low single-channel conductance and weak dependence on extracellular potassium, properties traced to a methionine at the position occupied by arginine in other Kir channels. Kir7.1 is concentrated at the apical membrane of retinal pigment epithelium, where it colocalizes with the sodium pump and sets subretinal potassium levels, and it is also expressed in choroid plexus, thyroid, and uterine smooth muscle. Human mutations cause snowflake vitreoretinal degeneration through dominant-negative gating changes and Leber congenital amaurosis type 16 through recessive loss of function, giving a clear allele fork between knockin and null. Constitutive mouse nulls die within a day of birth with cleft palate and feeding failure, so retinal pigment epithelium-restricted conditional deletion using Best1-Cre or an inducible driver is required to study photoreceptor survival and electroretinogram c-wave endpoints in adults, and humanized alleles support gene replacement testing.
What Kcnj13 mouse models are available?
ingenious targeting laboratory offers 3 distinct Kcnj13 (KCNJ13) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kcnj13 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kcnj13 allele types
Knockout, conditional, knockin, humanized, and related paths for Kcnj13 (human KCNJ13). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kcnj13 catalog models
3 Kcnj13 lines with QC documentation and technical support. Kcnj13 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Kcnj13-Flox
CKOCKO
These mice carry loxP sites flanking exon 2-3 of Kcnj13 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Kcnj13 gene.
Embryo CryopreservedCKO 200339 - Order
Kcnj13-CreERT2
KICre/Dre Toolbox
The Kozak-CreERT2-WPRE-pA expression cassette was knocked into the Kcnj13 gene start codon site.
Sperm CryopreservedKI 241142 - Order
Kcnj13-KO
KOKO
exon 2-3 of Kcnj13 gene was deleted to generate Kcnj13 knockout mice.
F0 Embryo CryopreservedKO 210183
Looking for a Kcnj13 mouse model?
We have 3 Kcnj13 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kcnj13 Mouse Model Types
A Kcnj13 knockout mouse has the Kcnj13 gene permanently inactivated, enabling loss of function studies. A Kcnj13 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kcnj13, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Kcnj13 knockin models carry a precisely inserted sequence at the Kcnj13 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Kcnj13 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Kcnj13 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.