Conventional / global / constitutive KO
●3 Models Available
Kcnj13 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Kcnj13 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Kcnj13 conditional knockout mouse, Kcnj13 knockin mouse, Kcnj13 knockout mouse. Request a quote within 24 hours.
Why model Kcnj13
Kcnj13, the mouse ortholog of human KCNJ13, encodes Kir7.1, an atypical inward rectifier with unusually low single-channel conductance and weak dependence on extracellular potassium, properties traced to a methionine at the position occupied by arginine in other Kir channels. Kir7.1 is concentrated at the apical membrane of retinal pigment epithelium, where it colocalizes with the sodium pump and sets subretinal potassium levels, and it is also expressed in choroid plexus, thyroid, and uterine smooth muscle. Human mutations cause snowflake vitreoretinal degeneration through dominant-negative gating changes and Leber congenital amaurosis type 16 through recessive loss of function, giving a clear allele fork between knockin and null. Constitutive mouse nulls die within a day of birth with cleft palate and feeding failure, so retinal pigment epithelium-restricted conditional deletion using Best1-Cre or an inducible driver is required to study photoreceptor survival and electroretinogram c-wave endpoints in adults, and humanized alleles support gene replacement testing.
What Kcnj13 mouse models are available?
ingenious targeting laboratory offers 3 distinct Kcnj13 (KCNJ13) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kcnj13 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kcnj13 allele types
Knockout, conditional, knockin, humanized, and related paths for Kcnj13 (human KCNJ13). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kcnj13 catalog models
3 Kcnj13 lines with QC documentation and technical support. Kcnj13 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kcnj13 mouse model?
We have 3 Kcnj13 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kcnj13 Mouse Model Types
A Kcnj13 knockout mouse has the Kcnj13 gene permanently inactivated, enabling loss of function studies. A Kcnj13 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kcnj13, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Kcnj13 knockin models carry a precisely inserted sequence at the Kcnj13 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Kcnj13 organized by modification type. Each URL is indexable and matches common search patterns.