Conventional / global / constitutive KO
●2 Models Available
Kctd15 Conditional Knockout, Knockout mouse models
Browse 2 Kctd15 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Kctd15 conditional knockout mouse, Kctd15 knockout mouse. Contact us for availability and fast turnaround.
Why model Kctd15
Kctd15, the mouse ortholog of human KCTD15, encodes a BTB and POZ domain protein that oligomerizes into pentamers and acts both as a Cullin3 E3 ligase adaptor and as a direct inhibitor of AP-2 transcription factors, a mechanism first defined in neural crest induction where KCTD15 restricts the crest domain at the neural plate border. In vertebrate development it also modulates Wnt and Nodal signaling, and in the hypothalamus it has been implicated in the melanocortin pathway, consistent with human GWAS signals near KCTD15 for body mass index and obesity risk. Related family members KCTD1 and KCTD15 share the AP-2 inhibitory activity, and the closely related KCTD12 and KCTD17 diverge functionally, so paralog-aware design matters. Conditional nulls with Wnt1-Cre address neural crest derivatives, while hypothalamic or Pomc-restricted deletion addresses energy balance, and Cullin3-binding-deficient knockins separate ligase-dependent from transcription factor-binding functions. Choose the allele that matches whether the endpoint is craniofacial patterning, adiposity, or transcriptional output.
What Kctd15 mouse models are available?
ingenious targeting laboratory offers 2 distinct Kctd15 (KCTD15) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kctd15 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kctd15 allele types
Knockout, conditional, knockin, humanized, and related paths for Kctd15 (human KCTD15). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kctd15 catalog models
2 Kctd15 lines with QC documentation and technical support. Kctd15 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kctd15 mouse model?
We have 2 Kctd15 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kctd15 Mouse Model Types
A Kctd15 knockout mouse has the Kctd15 gene permanently inactivated, enabling loss of function studies. A Kctd15 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kctd15, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kctd15 organized by modification type. Each URL is indexable and matches common search patterns.