Conventional / global / constitutive KO
●7 Models Available
Kit Conditional Knockout, Knockin, Knockout mouse models
Browse 7 Kit mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Kit conditional knockout mouse, Kit knockin mouse, Kit knockout mouse. Request a quote within 24 hours.
Why model Kit
Kit encodes the mouse ortholog of human KIT, a type III receptor tyrosine kinase with five extracellular immunoglobulin-like domains, an autoinhibitory juxtamembrane segment, and a split kinase domain that dimerizes upon binding stem cell factor (Kitl). Ligand engagement triggers trans-autophosphorylation and recruitment of PI3K, SRC family kinases, and the RAS-ERK cascade, sustaining mast cells, melanoblasts, hematopoietic progenitors, germ cells, and interstitial cells of Cajal. Oncogenic alleles fall into two mechanistic classes: juxtamembrane exon 11 deletions that relieve autoinhibition in gastrointestinal stromal tumor, and activation loop D816V substitutions that confer imatinib resistance in systemic mastocytosis and core binding factor leukemia. Conditional nulls therefore address lineage dependency, whereas knockin of the exact human hotspot codon models spontaneous tumorigenesis and inhibitor pharmacology; complete loss recapitulates the dominant white spotting phenotype with perinatal macrocytic anemia, so hypomorphic or inducible strategies preserve viability. Pair activating knockins with tissue-restricted Cre drivers to localize transformation and obtain clean drug response endpoints.
What Kit mouse models are available?
ingenious targeting laboratory offers 7 distinct Kit (KIT) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 7 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kit model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kit allele types
Knockout, conditional, knockin, humanized, and related paths for Kit (human KIT). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kit catalog models
7 Kit lines with QC documentation and technical support. Kit floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Kit-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 230161 - Order
Kit-V831M
Knockinpoint mutantion mice
embryo cryopreservationKI 190023 - Order
Kit-V831M(NOD-scid)
Knockinpoint mutantion mice, Immunodeficient mice
sperm cryopreservationKI 200316 - Order
Kit-V831M(M-NSG)
Knockinpoint mutantion mice, Immunodeficient mice
liveKI 242813 - Order
Kit-KO(3)
KnockoutKO/CKO mice
sperm cryopreservationKO 233471 - Order
Kit-KO
KnockoutKO/CKO mice
sperm cryopreservationKO 225108 - Order
Kit-KO(BALB/c)
KnockoutKO/CKO mice
sperm cryopreservationKO 232717
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Kit (KIT) from ITL supported projects.
- Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism familiesKittaka M, Mizuno N, Morino H, Yoshimoto T, TZhu T, Liu S, Wang Z, Mayahara K, Iio K, Kondo K, Kondo T, Hayashi T, Coghlan S, Teno Y, Anh Phung Doan A, Levitan M, Choi RB, Matsuda S, Ouhara K, Wan J, Cassidy AM, Pelletier S, Nampoothiri S, Urtizberea AJ, Robling AG, Ono M, Kawakami H, Reichenberger EJ, Ueki Y. (2024). JBMR Plus 8(6): ziae050
- Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production.Burzynski LC, Morales-Maldonado A, Rodgers A, Kitt LA, Humphry M, Figg N, Bennett MR, Clarke MCH. (2023). Cardiovasc Res 119(12): 2179-89
- Alveolar bone protection by targeting the SH3BP2-SYK axis in osteoclastsKittaka M, Yoshimoto T, Schlosser C, Rottapel R, Kajiya M, Kurihara H, Reichenberger EJ, Ueki Y. (2020). J Bone Miner Res 35(2): 382-395
- The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by ThrombinBurzynski LC, Humphry M, Pyrillou K, Wiggins KA, Chan JNE, Figg N, Kitt LL, Summers C, Tatham KC, Martin PB, Bennett MR, Clarke MCH. (2019). Immunity 50(4): 1033-1042.e6
- Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits.Kohara K, Pignatelli M, Rivest AJ, Jung HY, Kitamura T, Suh J, Frank D, Kajikawa K, Mise N, Obata Y, Wickersham IR, Tonegawa S. (2014). Nat Neurosci 17: 269-279
Looking for a Kit mouse model?
We have 7 Kit models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model7
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kit Mouse Model Types
A Kit knockout mouse has the Kit gene permanently inactivated, enabling loss of function studies. A Kit conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kit, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Kit knockin models carry a precisely inserted sequence at the Kit locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Kit organized by modification type. Each URL is indexable and matches common search patterns.