What Kras Conditional Knockout mouse models are available?

When Kras Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Kras knockout embryonic lethal in mice?

It depends on background and allele design. Some Kras germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Kras animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Kras?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●10 Models Available

Kras Conditional Knockout, Knockin, Knockout mouse models

Browse 10 Kras mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Kras conditional knockout mouse, Kras knockin mouse, Kras knockout mouse, Kras xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Kras

Kras, the mouse ortholog of human KRAS, encodes the Ras isoform on which most epithelial tumors depend, a GTPase governed by Sos1-mediated exchange and by Nf1 and Rasa1 GAP activity, coupling receptor input to Raf, PI3K, and Ral effectors; unlike Hras it is farnesylated without palmitoylation and carries a polybasic hypervariable region, and alternative fourth-exon splicing produces the 4A and 4B isoforms with different membrane behavior. Codon 12, 13, and 61 substitutions abolish GAP-stimulated hydrolysis, and allele identity matters pharmacologically, since Gly12Cys and Gly12Asp are addressed by chemically distinct inhibitors. Homozygous deletion is embryonic lethal, uniquely among Ras genes, so conditional nulls are required, while Lox-Stop-Lox oncogenic knockins expressed at endogenous levels remain the standard for tumor initiation and humanization enables clinical-compound pharmacokinetic and pharmacodynamic testing. Hras and Nras can substitute developmentally when knocked into the Kras locus, evidence that dosage and localization, not sequence identity, drive the essential requirement.

What Kras mouse models are available?

ingenious targeting laboratory offers 10 distinct Kras (KRAS) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
10 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Kras model types

PathAvailability

Knockout
View catalog
Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Kras allele types

Knockout, conditional, knockin, humanized, and related paths for Kras (human KRAS). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

Browse Full Catalog

Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

Request a Quote Explore model generation services

Available Kras catalog models

10 Kras lines with QC documentation and technical support. Kras floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Kras-Flox
Conditional Knockout
KO/CKO mice
sperm cryopreservationCKO 2101910
Order
Kras-LSL-G12D/R26-CAG-LSL-Luc-2A-EGFP
Knockin
over expression mice, fluorescent mouse
embryo cryopreservationKI 234718
Order
Kras-LSL-G12C
Knockin
point mutantion mice
In production — inquireKI 240768
Order
Kras-LSL-G12V
Knockin
point mutantion mice
sperm cryopreservationKI 231383
Order
Kras-RSR-G12D
Knockin
point mutantion mice
sperm cryopreservationKI 210436
Order
Kras-LSL-G12D
Knockin
point mutantion mice, disease model mice
liveKI 190003
Order
Kras-KO
Knockout
KO/CKO mice
sperm cryopreservationKO 230318
Order
Kras-LSL-G12D/Pdx1-Cre-Tg/Tgfbr2-Flox
Xenograft-Applicable
KO/CKO mice,point mutantion mice,Cre/Dre Toolbox of Mice, disease model mice, random transgenic mice
embryo cryopreservationXA 234935
Order
Kras-LSL-G12D/Trp53-LSL-R172H
Xenograft-Applicable
point mutantion mice
liveXA 253119
Order
Kras-LSL-G12D/Trp53-LSL-R172H/Pdx1-2A-Cre
Xenograft-Applicable
Cre/Dre Toolbox of Mice
liveXA 242420
Order

Selected publications from ingenious targeting laboratory

Peer reviewed work involving Kras (KRAS) from ITL supported projects.

Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophyFernandez-Caggiano M, Kamynina A, Francois AA, Prysyazhna O, Eykyn TR, Krasemann S, Crespo-Leiro MG, Vieites MG, Bianchi K, Morales V, Domenech N, Eaton P. (2020). Nat Metab 2(11): 1223-1231
Neonatal Tbr1 Dosage Controls Cortical Layer 6 ConnectivityFazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR. (2018). Neuron 100(4): 831-845.e7
A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degenerationChavali VR, Khan NW, Cukras CA, Bartsch DU, Jablonski MM, Ayyagari R. (2011). Hum Mol Genet 20(10): 2000-14

View all ITL publications

Looking for a Kras mouse model?

We have 10 Kras models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Kras Mouse Model Types

A Kras knockout mouse has the Kras gene permanently inactivated, enabling loss of function studies. A Kras conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kras, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Kras knockin models carry a precisely inserted sequence at the Kras locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Kras organized by modification type. Each URL is indexable and matches common search patterns.

Kras Conditional Knockout Kras Knockin Kras Knockout Kras Xenograft-Applicable Kras cDNA Knockin Kras Epitope Tag Knockin Kras Humanized Kras Inducible Knockout Kras Overexpression / Safe Harbor Kras Reporter

Tissue-specific options

Catalog backed tissue and driver restricted routes for Kras.

liver Kras conditional knockout