Conventional / global / constitutive KO
●2 Models Available
Ldha Conditional Knockout, Knockout mouse models
Browse 2 Ldha mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ldha conditional knockout mouse, Ldha knockout mouse. Request a quote within 24 hours.
Why model Ldha
Ldha encodes the mouse ortholog of human LDHA, the M subunit of lactate dehydrogenase, which assembles into homotetramers and hybrid tetramers with LDHB and preferentially reduces pyruvate to lactate while regenerating cytosolic NAD+, sustaining glycolysis when oxidative capacity or oxygen delivery is limiting. Transcription is driven by HIF1A and MYC, making the gene a canonical Warburg effector, and human LDHA deficiency causes glycogen storage disease type XI with exertional myoglobinuria and a blunted rise in blood lactate during ischemic exercise testing. Allele options map to distinct questions: a conditional null with Ckmm-Cre or a tumor-restricted Cre tests glycolytic dependence and lactate export, patient missense knockins reproduce partial deficiency and exercise-triggered rhabdomyolysis, and humanization supports LDHA inhibitor pharmacology. Because Ldhb is co-expressed and forms hybrid tetramers retaining activity, isoform-resolved zymography is required before attributing changes to LDHA. Match allele to endpoint, whether lactate flux and NAD+ to NADH ratio, tumor growth, or ischemic exercise physiology.
What Ldha mouse models are available?
ingenious targeting laboratory offers 2 distinct Ldha (LDHA) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ldha model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ldha allele types
Knockout, conditional, knockin, humanized, and related paths for Ldha (human LDHA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Ldha mouse model?
We have 2 Ldha models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ldha Mouse Model Types
A Ldha knockout mouse has the Ldha gene permanently inactivated, enabling loss of function studies. A Ldha conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ldha, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ldha organized by modification type. Each URL is indexable and matches common search patterns.