Conventional / global / constitutive KO
●1 Model Available
Ldhb Conditional Knockout mouse model
Browse 1 Ldhb mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Ldhb
Human LDHB has as its mouse ortholog Ldhb, encoding the H subunit of lactate dehydrogenase, which forms tetramers with a lower Km for lactate and is inhibited by high pyruvate, biasing flux toward lactate oxidation and NADH generation in heart, red muscle and other oxidative tissues where imported lactate serves as fuel within the cell to cell lactate shuttle. This directional preference makes the isoform central to lactate consumption rather than production, and its loss shifts tissues toward pyruvate reduction and lactate accumulation; LDHB has also been implicated in lysosomal acidification and autophagy and is silenced by promoter methylation in several tumors. A conditional null with Myh6-Cre or Ckmm-Cre tests reliance on lactate oxidation under workload, whereas humanized knockins support isoform-selective inhibitor programs where sparing LDHA is the goal. Ldha co-expression yields hybrid tetramers retaining bidirectional activity, so quantify isoenzyme patterns. Align allele with arteriovenous lactate difference, lactate tracing, stress echocardiography and autophagic flux endpoints.
What Ldhb mouse models are available?
ingenious targeting laboratory offers 1 distinct Ldhb (LDHB) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ldhb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ldhb allele types
Knockout, conditional, knockin, humanized, and related paths for Ldhb (human LDHB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ldhb catalog models
1 Ldhb line with QC documentation and technical support. Ldhb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ldhb-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 2118668
Looking for a Ldhb mouse model?
We have 1 Ldhb model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ldhb Mouse Model Types
A Ldhb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ldhb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ldhb organized by modification type. Each URL is indexable and matches common search patterns.