Conventional / global / constitutive KO
●2 Models Available
Lrp5 Conditional Knockout, Knockout mouse models
Browse 2 Lrp5 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Lrp5 conditional knockout mouse, Lrp5 knockout mouse. Request a quote within 24 hours.
Why model Lrp5
Lrp5, the mouse ortholog of human LRP5, encodes a single-pass LDL receptor-related Wnt co-receptor whose extracellular region comprises four beta-propeller and EGF module pairs; upon Wnt binding it is brought together with Frizzled, and CK1gamma and Gsk3 phosphorylation of reiterated PPPSPXS motifs in its cytoplasmic tail creates the Axin docking site that disables the beta-catenin destruction complex. The first propeller is the binding surface for the antagonists Dkk1 and Sost, which explains why the Gly171Val high bone mass substitution acts by escaping sclerostin inhibition rather than by increasing intrinsic activity, while loss-of-function alleles cause osteoporosis-pseudoglioma syndrome and familial exudative vitreoretinopathy. Nulls are viable with low bone mass and persistent hyaloid vasculature, so germline and conditional alleles are both practical, and the high bone mass knockin or a humanized propeller is the correct design for sclerostin antibody and Dkk1 blockade studies. Lrp6 overlaps functionally, so compound alleles reveal masked skeletal phenotypes.
What Lrp5 mouse models are available?
ingenious targeting laboratory offers 2 distinct Lrp5 (LRP5) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Lrp5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Lrp5 allele types
Knockout, conditional, knockin, humanized, and related paths for Lrp5 (human LRP5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Lrp5 catalog models
2 Lrp5 lines with QC documentation and technical support. Lrp5 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Lrp5 mouse model?
We have 2 Lrp5 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Lrp5 Mouse Model Types
A Lrp5 knockout mouse has the Lrp5 gene permanently inactivated, enabling loss of function studies. A Lrp5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Lrp5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Lrp5 organized by modification type. Each URL is indexable and matches common search patterns.