Conventional / global / constitutive KO
●3 Models Available
Lrrk2 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Lrrk2 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Lrrk2 conditional knockout mouse, Lrrk2 knockin mouse, Lrrk2 knockout mouse. Contact us for availability and fast turnaround.
Why model Lrrk2
Lrrk2, the mouse ortholog of human LRRK2, encodes a large multidomain protein combining armadillo, ankyrin, and leucine-rich repeats with a ROC GTPase domain, a COR linker, a serine/threonine kinase domain, and a WD40 tail, functioning as a dimeric kinase recruited to damaged or stressed membranes. Its validated substrates are a subset of Rab GTPases, including Rab8a, Rab10, and Rab29, phosphorylated at a conserved threonine in the switch II motif, which blocks GDI binding and reroutes membrane trafficking, ciliogenesis, and lysosomal repair. The G2019S mutation in the kinase domain and R1441C/G in the ROC domain increase Rab10 phosphorylation and cause autosomal dominant Parkinson disease, so knockin alleles, not deletion, reproduce the disease mechanism, while nulls are viable but develop kidney and lung lamellar body pathology that constrains interpretation and mirrors the on-target liability of kinase inhibitors. Kinase-dead knockins separate scaffolding from catalysis; use phospho-Rab10 as the pharmacodynamic endpoint.
What Lrrk2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Lrrk2 (LRRK2) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Lrrk2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Lrrk2 allele types
Knockout, conditional, knockin, humanized, and related paths for Lrrk2 (human LRRK2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Lrrk2 catalog models
3 Lrrk2 lines with QC documentation and technical support. Lrrk2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Lrrk2 mouse model?
We have 3 Lrrk2 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Lrrk2 Mouse Model Types
A Lrrk2 knockout mouse has the Lrrk2 gene permanently inactivated, enabling loss of function studies. A Lrrk2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Lrrk2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Lrrk2 knockin models carry a precisely inserted sequence at the Lrrk2 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Lrrk2 organized by modification type. Each URL is indexable and matches common search patterns.