Conventional / global / constitutive KO
●1 Model Available
Mapk1 Conditional Knockout mouse model
Browse 1 Mapk1 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Mapk1
Mapk1, the mouse ortholog of human MAPK1, encodes ERK2, the more abundant of the two classical extracellular signal-regulated kinases, activated by MEK1 and MEK2 phosphorylation of the Thr and Tyr residues in its TEY motif and directing substrate choice through a common docking groove and an F-site that recognize DEF and D-domain motifs in Rsk kinases, Elk1, Fos, and Myc, where it phosphorylates Ser62 to stabilize the protein; Dusp6 and Spry proteins impose negative feedback. Homozygous nulls die in early gestation from trophoblast and placental failure, so conditional alleles are required, and allele class separates questions cleanly: floxed deletion tests tissue dependence, an analog-sensitive gatekeeper mutant enables acute kinase inhibition without adaptive rewiring, and knock-in reporters such as kinase translocation constructs quantify signaling dynamics rather than presence. Mapk3-encoded ERK1 is a genuine paralog whose null is viable, and total ERK dosage rather than isoform identity governs most phenotypes, so plan compound alleles accordingly.
What Mapk1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Mapk1 (MAPK1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mapk1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mapk1 allele types
Knockout, conditional, knockin, humanized, and related paths for Mapk1 (human MAPK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mapk1 catalog models
1 Mapk1 line with QC documentation and technical support. Mapk1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Mapk1-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 230225
Looking for a Mapk1 mouse model?
We have 1 Mapk1 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mapk1 Mouse Model Types
A Mapk1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mapk1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Mapk1 organized by modification type. Each URL is indexable and matches common search patterns.