Conventional / global / constitutive KO
●3 Models Available
Mlh1 Conditional Knockout, Knockout mouse models
Browse 3 Mlh1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Mlh1 conditional knockout mouse, Mlh1 knockout mouse. Request a quote within 24 hours.
Why model Mlh1
Mlh1, the mouse ortholog of human MLH1, encodes the obligate partner of the MutL family, dimerizing with Pms2 to form MutLalpha, and less commonly with Mlh3 or Pms1; recruited by mismatch-bound MutSalpha, the complex uses ATP binding and the latent Pms2 endonuclease to nick the nascent strand, licensing Exo1-mediated excision and resynthesis, and it separately cooperates with Mlh3 to resolve meiotic recombination intermediates into crossovers. Germline loss causes Lynch syndrome with microsatellite instability, and somatic promoter hypermethylation silences it in sporadic colorectal and endometrial cancer. Homozygous nulls are viable but cancer-prone and sterile from meiotic failure, so conditional alleles are the way to study tissue-restricted repair loss without confounding infertility. Endonuclease-dead and dimerization-selective knockins separate repair from crossover functions, while humanization enables functional classification of variants of uncertain significance. Mlh3 and Pms1 partially cover meiotic roles but cannot substitute for MutLalpha in repair, so compensation is limited.
What Mlh1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Mlh1 (MLH1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mlh1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mlh1 allele types
Knockout, conditional, knockin, humanized, and related paths for Mlh1 (human MLH1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mlh1 catalog models
3 Mlh1 lines with QC documentation and technical support. Mlh1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Mlh1 mouse model?
We have 3 Mlh1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mlh1 Mouse Model Types
A Mlh1 knockout mouse has the Mlh1 gene permanently inactivated, enabling loss of function studies. A Mlh1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mlh1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Mlh1 organized by modification type. Each URL is indexable and matches common search patterns.