Conventional / global / constitutive KO
●3 Models Available
Myd88 Conditional Knockout, Knockout mouse models
Browse 3 Myd88 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Myd88 conditional knockout mouse, Myd88 knockout mouse. Contact us for availability and fast turnaround.
Why model Myd88
Myd88, the mouse ortholog of human MYD88, encodes the universal TIR domain adaptor for every Toll-like receptor except TLR3 and for IL-1R, IL-18R, and IL-33R, using its death domain to nucleate a helical Myddosome with IRAK4 and IRAK1 or IRAK2 that activates TRAF6, TAK1, IKK, and MAPK signaling. Human MYD88 deficiency yields severe pyogenic bacterial infection with otherwise intact immunity, while the recurrent L265P substitution in the TIR domain drives spontaneous Myddosome assembly and constitutive NF-kB in Waldenstrom macroglobulinemia and activated B cell diffuse large B cell lymphoma, cooperating with CD79B in a B cell receptor associated supercomplex. This split biology dictates the allele fork precisely: a conditional null tests requirement for innate sensing, and an L265P knockin, ideally Cd19-Cre or Aicda-Cre restricted and inducible, models the lymphoma. Since germline null phenotypes are strongly microbiota dependent, use littermate controls and defined flora rather than cross-facility comparisons.
What Myd88 mouse models are available?
ingenious targeting laboratory offers 3 distinct Myd88 (MYD88) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Myd88 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Myd88 allele types
Knockout, conditional, knockin, humanized, and related paths for Myd88 (human MYD88). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Myd88 catalog models
3 Myd88 lines with QC documentation and technical support. Myd88 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Myd88 mouse model?
We have 3 Myd88 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Myd88 Mouse Model Types
A Myd88 knockout mouse has the Myd88 gene permanently inactivated, enabling loss of function studies. A Myd88 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Myd88, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Myd88 organized by modification type. Each URL is indexable and matches common search patterns.