Conventional / global / constitutive KO
●3 Models Available
Nf1 Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 3 Nf1 mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Nf1 conditional knockout mouse, Nf1 knockout mouse, Nf1 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Nf1
Neurofibromin, encoded by mouse Nf1 in orthology with human NF1, is a large cytoplasmic protein whose central GAP-related domain accelerates GTP hydrolysis on RAS, making it the principal brake on RAS-RAF-MEK-ERK and, indirectly, on mTORC1 output; flanking regions mediate SPRED1-dependent membrane recruitment and adenylyl cyclase modulation. Germline heterozygous truncations cause neurofibromatosis type 1, and somatic second hits in Schwann cell precursors, astrocytes, or myeloid progenitors generate plexiform neurofibroma, malignant peripheral nerve sheath tumor, optic pathway glioma, and juvenile myelomonocytic leukemia, while biallelic inactivation also recurs in glioblastoma and melanoma. Because germline nulls die near midgestation from cardiac outflow tract defects, conditional nulls are standard, with Dhh-cre or Krox20-cre for Schwann cell lineages and Gfap-cre for glioma, typically on an Nf1 heterozygous background to reproduce haploinsufficient stroma. Match allele class to endpoint: nulls for tumor initiation and MEK inhibitor response, humanized or specific missense knockins for variant interpretation.
What Nf1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Nf1 (NF1) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Nf1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Nf1 allele types
Knockout, conditional, knockin, humanized, and related paths for Nf1 (human NF1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Nf1 catalog models
3 Nf1 lines with QC documentation and technical support. Nf1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Nf1 mouse model?
We have 3 Nf1 models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Nf1 Mouse Model Types
A Nf1 knockout mouse has the Nf1 gene permanently inactivated, enabling loss of function studies. A Nf1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Nf1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Nf1 organized by modification type. Each URL is indexable and matches common search patterns.