Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
LIVE · DEVELOPING
Nf2 Conditional Knockout, Xenograft-Applicable mouse models
Browse 2 Nf2 mouse models including conditional knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Nf2 conditional knockout mouse, Nf2 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Nf2
Merlin, the product of mouse Nf2 and ortholog of human NF2, is a FERM domain cytoskeletal adaptor that couples cortical actin and adherens junctions to growth control, restraining the Hippo pathway by promoting LATS1 and LATS2 activation and YAP or TAZ phosphorylation, and separately entering the nucleus to inhibit the CRL4-DCAF1 E3 ligase. Biallelic inactivation underlies familial and sporadic schwannoma, meningioma, ependymoma, and a large fraction of malignant pleural mesothelioma, with tumorigenesis proceeding through unrestrained YAP-TEAD transcription rather than kinase hyperactivation. Germline nulls fail at gastrulation because of extraembryonic defects, so conditional nulls are mandatory: P0-cre or Postn-cre for Schwann cells, Wt1-cre for mesothelium, each yielding distinct tumor spectra. Compensation is limited, since the ezrin, radixin, and moesin family shares the FERM fold without recapitulating growth suppression. Choose nulls for tumor initiation and TEAD inhibitor sensitivity, and consider humanized alleles where clinical missense variants must be functionally classified.
What Nf2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Nf2 (NF2) catalog mouse models, featuring conditional knockout and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Nf2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Nf2 allele types
Knockout, conditional, knockin, humanized, and related paths for Nf2 (human NF2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Nf2 catalog models
2 Nf2 lines with QC documentation and technical support. Nf2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Nf2-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 2 of Nf2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf2 gene.
LiveCKO 200017 - Order
Nf2-Flox/Dhh-Cre
XACKO, Cre/Dre Toolbox
The Nf2-Flox (CKO 200017) was crossed with Dhh-Cre(KI 225049) to generate Nf2-Flox/Dhh-Cre mice.
In DevelopmentXA 254202
Looking for a Nf2 mouse model?
We have 2 Nf2 models in stock — including Conditional Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Nf2 Mouse Model Types
A Nf2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Nf2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Nf2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Nf2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.