Conventional / global / constitutive KO
●2 Models Available
Nlgn3 Conditional Knockout, Knockout mouse models
Browse 2 Nlgn3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Nlgn3 conditional knockout mouse, Nlgn3 knockout mouse. Contact us for availability and fast turnaround.
Why model Nlgn3
Nlgn3, the mouse ortholog of X-linked human NLGN3, encodes neuroligin-3, the only neuroligin found at both excitatory and inhibitory synapses, where its cholinesterase-like ectodomain binds neurexins and its cytoplasmic tail couples to PSD-95 or gephyrin scaffolds depending on synapse class. Neuroligin-3 is also required for tonic endocannabinoid signaling at hippocampal inhibitory synapses, and its ectodomain is cleaved by ADAM10 in an activity-dependent manner, with the shed fragment acting as a mitogen for glioma cells, a striking non-synaptic function. The autism-associated R451C substitution in the cholinesterase-like domain causes protein retention in the endoplasmic reticulum yet behaves as a gain of function in vivo, increasing inhibitory transmission and producing social behavior deficits, whereas the null shows a distinct and partly opposite profile, so knockin and deletion answer genuinely different questions. Because Nlgn1 and Nlgn2 occupy overlapping synapse classes, conditional alleles paired with cell-type Cre drivers and synapse-resolved recordings are the appropriate design.
What Nlgn3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Nlgn3 (NLGN3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Nlgn3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Nlgn3 allele types
Knockout, conditional, knockin, humanized, and related paths for Nlgn3 (human NLGN3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Nlgn3 catalog models
2 Nlgn3 lines with QC documentation and technical support. Nlgn3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Nlgn3 mouse model?
We have 2 Nlgn3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Nlgn3 Mouse Model Types
A Nlgn3 knockout mouse has the Nlgn3 gene permanently inactivated, enabling loss of function studies. A Nlgn3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Nlgn3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Nlgn3 organized by modification type. Each URL is indexable and matches common search patterns.