Conventional / global / constitutive KO
●3 Models Available
Nrg1 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Nrg1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Nrg1 conditional knockout mouse, Nrg1 knockin mouse, Nrg1 knockout mouse. Request a quote within 24 hours.
Why model Nrg1
Nrg1, the mouse ortholog of human NRG1, encodes neuregulin 1, a family of EGF-domain ligands generated from a single locus through multiple promoters and splice choices that yield type I and type II isoforms with immunoglobulin-like amino termini, type III isoforms with a cysteine-rich transmembrane region that signal juxtacrine, and alpha or beta EGF variants with different receptor affinity. Most isoforms are made as transmembrane precursors cleaved by Bace1 and Adam17 to release the EGF domain, which binds Erbb3 or Erbb4 and drives heterodimerization with Erbb2 to activate PI3K and Erk. Homozygous nulls die at mid-gestation from failed cardiac trabeculation, so isoform-specific conditional exon targeting is the design that isolates type III-dependent Schwann cell myelination or type I-dependent cardiac and interneuron phenotypes. Human NRG1 fusions in lung adenocarcinoma justify fusion knockins, and Nrg2, Nrg3, and Nrg4 provide overlapping Erbb ligands that can mask single-gene loss.
What Nrg1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Nrg1 (NRG1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Nrg1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Nrg1 allele types
Knockout, conditional, knockin, humanized, and related paths for Nrg1 (human NRG1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Nrg1 catalog models
3 Nrg1 lines with QC documentation and technical support. Nrg1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Nrg1 mouse model?
We have 3 Nrg1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Nrg1 Mouse Model Types
A Nrg1 knockout mouse has the Nrg1 gene permanently inactivated, enabling loss of function studies. A Nrg1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Nrg1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Nrg1 knockin models carry a precisely inserted sequence at the Nrg1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Nrg1 organized by modification type. Each URL is indexable and matches common search patterns.