Conventional / global / constitutive KO
●2 Models Available
Ntrk1 Conditional Knockout, Knockout mouse models
Browse 2 Ntrk1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ntrk1 conditional knockout mouse, Ntrk1 knockout mouse. Request a quote within 24 hours.
Why model Ntrk1
TrkA, encoded by mouse Ntrk1 in orthology with human NTRK1, is a receptor tyrosine kinase with leucine-rich repeats and immunoglobulin-like C2 modules that binds nerve growth factor, dimerizes, and signals through SHC, FRS2, phospholipase C gamma, and the RAS-ERK and PI3K-AKT cascades to specify survival of nociceptive sensory and sympathetic neurons. Biallelic loss-of-function variants cause congenital insensitivity to pain with anhidrosis, whereas oncogenic activation occurs through in-frame fusions such as LMNA-NTRK1 and TPM3-NTRK1 that dimerize constitutively via partner coiled coils, defining a tumor-agnostic indication for larotrectinib and entrectinib along with solvent front resistance at G595. Design therefore separates three questions: nulls for sensory neuron development and pain phenotypes, inducible fusion knockins for oncogenic dependency and inhibitor pharmacology, and humanized kinase domains for potency and resistance profiling. Germline nulls survive to birth but die early with severe sensory ganglion loss, so tissue-restricted deletion is preferable, and Ntrk2 and Ntrk3 bind distinct neurotrophins without compensating.
What Ntrk1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ntrk1 (NTRK1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ntrk1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ntrk1 allele types
Knockout, conditional, knockin, humanized, and related paths for Ntrk1 (human NTRK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ntrk1 catalog models
2 Ntrk1 lines with QC documentation and technical support. Ntrk1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ntrk1 mouse model?
We have 2 Ntrk1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ntrk1 Mouse Model Types
A Ntrk1 knockout mouse has the Ntrk1 gene permanently inactivated, enabling loss of function studies. A Ntrk1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ntrk1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ntrk1 organized by modification type. Each URL is indexable and matches common search patterns.