Conventional / global / constitutive KO
●3 Models Available
Ntrk2 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Ntrk2 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ntrk2 conditional knockout mouse, Ntrk2 knockin mouse, Ntrk2 knockout mouse. Request a quote within 24 hours.
Why model Ntrk2
Mouse Ntrk2, ortholog of human NTRK2, encodes TrkB, the high affinity receptor for brain-derived neurotrophic factor and neurotrophin 4, whose ligand-induced dimerization activates SHC-RAS-ERK, PI3K-AKT, and phospholipase C gamma 1 signaling to control neuronal survival, dendritic arborization, synaptic potentiation, and hypothalamic energy balance. Alternative splicing generates the kinase-dead TrkB.T1 isoform, which acts as a dominant negative ligand sink and predominates in glia, an isoform architecture that targeting vectors must respect. Human loss-of-function variants produce hyperphagic obesity with developmental delay, while NTRK2 fusions occur in pilocytic astrocytoma and glioblastoma. Germline nulls die within days of birth with severe sensory and motor deficits, so conditional deletion using Camk2a-cre, Nes-cre, or Sim1-cre is required for adult circuit and metabolic endpoints, and isoform-selective alleles are needed to separate full length from truncated receptor function. Ntrk1 and Ntrk3 bind different neurotrophins and do not rescue, so match allele class to whether the question is circuit signaling, obesity, or fusion-driven glioma.
What Ntrk2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Ntrk2 (NTRK2) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ntrk2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ntrk2 allele types
Knockout, conditional, knockin, humanized, and related paths for Ntrk2 (human NTRK2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ntrk2 catalog models
3 Ntrk2 lines with QC documentation and technical support. Ntrk2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ntrk2 mouse model?
We have 3 Ntrk2 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ntrk2 Mouse Model Types
A Ntrk2 knockout mouse has the Ntrk2 gene permanently inactivated, enabling loss of function studies. A Ntrk2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ntrk2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Ntrk2 knockin models carry a precisely inserted sequence at the Ntrk2 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Ntrk2 organized by modification type. Each URL is indexable and matches common search patterns.