Conventional / global / constitutive KO
●2 Models Available
Optn Conditional Knockout, Knockout mouse models
Browse 2 Optn mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Optn conditional knockout mouse, Optn knockout mouse. Request a quote within 24 hours.
Why model Optn
Optineurin, encoded by mouse Optn and orthologous to human OPTN, is a coiled-coil autophagy receptor carrying an LC3-interacting region, a UBAN motif that binds linear M1-linked polyubiquitin, and a C-terminal zinc finger. TBK1 phosphorylates optineurin at Ser177 and adjacent residues to enhance LC3 binding and ubiquitin affinity, driving mitophagy downstream of PINK1 and parkin, xenophagy of cytosolic bacteria, and clearance of aggregated protein, while the UBAN domain simultaneously restrains NF-kappaB signaling. Disease logic is allele-specific: E50K acts as a dominant gain of function in normal-tension glaucoma, whereas E478G and truncating alleles cause ALS by abolishing ubiquitin binding. Model designs therefore fork between conditional null, UBAN point knockins such as D477N, phosphomimetic or phosphodead Ser177 variants, and humanization. Because Sqstm1, Nbr1, Tax1bp1, and Calcoco2 provide overlapping receptor activity, expect buffered clearance phenotypes and pair conditional alleles with motor neuron or microglial Cre drivers.
What Optn mouse models are available?
ingenious targeting laboratory offers 2 distinct Optn (OPTN) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Optn model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Optn allele types
Knockout, conditional, knockin, humanized, and related paths for Optn (human OPTN). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Optn catalog models
2 Optn lines with QC documentation and technical support. Optn floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Optn mouse model?
We have 2 Optn models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Optn Mouse Model Types
A Optn knockout mouse has the Optn gene permanently inactivated, enabling loss of function studies. A Optn conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Optn, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Optn organized by modification type. Each URL is indexable and matches common search patterns.